The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers

Janet L. Pitman, Alan S. McNeilly, Judy R. McNeilly, Laura E. Hays, Grover C. Bagby, Heywood R. Sawyer, Kenneth P. McNatty

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    This review examines the importance of the epithelial origin of granulosa cells and their possible contribution to the development of ovarian cancers in three animal models.We hypothesise that undifferentiated granulosa cells, devoid of their germ cell regulator, retain their embryonic plasticity and may give rise to ovarian cancers of epithelial origin. Dazl-KO and FancD2-KO mice and BMP15-KO sheep are animal models in which germ cells or oocytes are lost at specific stages of follicular formation or growth, leaving behind clusters of residual, but healthy somatic cells. A common feature in Dazl- and Fancd2-KO animals following germ cell/oocyte loss is the presence of sex cords and intraovarian epithelial ducts or tubules. In Dazl-KO mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign. In Fancd2-KO mice, the formation of sex-cords and intraovarian tubules lead to the formation of tumours with multiple phenotypes including luteomas, papillary cysts and malignant carcinomas (e.g. adenocarcinomas). In BMP15-KO sheep, oocytes die as follicles start to grow, leaving 'nodules' containing granulosa cells with a capacity to respond to follicle stimulating hormone and synthesize inhibin.Thereafter, these nodules coalesced and a range of benign solid or semi-solid tumour phenotypes developed. We conclude that premature loss of oocytes, but not granulosa cells, leads to tumour formation with multiple phenotypes. Moreover, the severity of tumour development is linked to both the specificity of the mutation and the timing of oocyte loss relative to that of follicular formation.

    Original languageEnglish (US)
    Pages (from-to)949-958
    Number of pages10
    JournalInternational Journal of Developmental Biology
    Volume56
    Issue number10-12
    DOIs
    StatePublished - 2012

    Fingerprint

    Granulosa Cells
    Ovarian Neoplasms
    Oocytes
    Germ Cells
    Phenotype
    Luteoma
    Neoplasms
    Sheep
    Animal Models
    Inhibins
    Follicle Stimulating Hormone
    Cysts
    Adenocarcinoma
    Carcinoma
    Mutation
    Growth

    Keywords

    • Epithelium
    • Germ cell
    • Intraovarian tubule
    • Sex cord
    • Tumor

    ASJC Scopus subject areas

    • Developmental Biology
    • Embryology

    Cite this

    The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers. / Pitman, Janet L.; McNeilly, Alan S.; McNeilly, Judy R.; Hays, Laura E.; Bagby, Grover C.; Sawyer, Heywood R.; McNatty, Kenneth P.

    In: International Journal of Developmental Biology, Vol. 56, No. 10-12, 2012, p. 949-958.

    Research output: Contribution to journalArticle

    Pitman, Janet L. ; McNeilly, Alan S. ; McNeilly, Judy R. ; Hays, Laura E. ; Bagby, Grover C. ; Sawyer, Heywood R. ; McNatty, Kenneth P. / The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers. In: International Journal of Developmental Biology. 2012 ; Vol. 56, No. 10-12. pp. 949-958.
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