The fanconi anaemia/BRCA pathway

Alan D. D'Andrea, Markus Grompe

Research output: Contribution to journalReview article

617 Scopus citations

Abstract

Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability - a common feature of many human cancers.

Original languageEnglish (US)
Pages (from-to)23-34
Number of pages12
JournalNature Reviews Cancer
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2003

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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