The expression of cocaine sensitization is not prevented by MK-801 or ibotenic acid lesions of the medial prefrontal cortex

Yong Li, Marina Wolf, Francis J. White

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Previous work has established that the development of cocaine sensitization is prevented by co-administration of the non-competitive NMDA receptor antagonist MK-801 or by prior ibotenic acid lesions of the medial prefrontal cortex (PFC). The present study examined the effect of these treatments on the expression of cocaine sensitization. Rats were treated with 15 mg/kg cocaine for 5 days and then challenged with cocaine 3 days later to establish the presence of sensitization. The next day, rats received 0.1 mg/kg MK-801 30 min before cocaine challenge. This dose of MK-801, which is sufficient to prevent the development of cocaine sensitization, did not prevent its expression. Rather, it augmented the response of sensitized rats to cocaine challenge and produced a non-significant trend towards augmentation of the acute response to cocaine in saline-pretreated rats. For PFC lesion experiments, rats were sensitized to cocaine and then received either ibotenic acid or sham lesions of the PFC. One week later, all rats were challenged with cocaine. Sham lesioned and ibotenic acid lesioned rats exhibited the same degree of sensitization. Thus, neither NMDA receptor transmission nor PFC projections appear necessary for the expression of cocaine sensitization. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalBehavioural Brain Research
Volume104
Issue number1-2
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

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Ibotenic Acid
Dizocilpine Maleate
Prefrontal Cortex
Cocaine
N-Methyl-D-Aspartate Receptors

Keywords

  • Behavioral sensitization
  • Cocaine
  • Excitatory amino acids
  • MK-801
  • Prefrontal cortex
  • Ventral tegmental area

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

The expression of cocaine sensitization is not prevented by MK-801 or ibotenic acid lesions of the medial prefrontal cortex. / Li, Yong; Wolf, Marina; White, Francis J.

In: Behavioural Brain Research, Vol. 104, No. 1-2, 01.10.1999, p. 119-125.

Research output: Contribution to journalArticle

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