The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors

Rory K. Morgan, Garret R. Anderson, Demet Araç, Gabriela Aust, Nariman Balenga, Antony Boucard, James P. Bridges, Felix B. Engel, Caroline J. Formstone, Maike D. Glitsch, Ryan S. Gray, Randy A. Hall, Cheng Chih Hsiao, Hee Yong Kim, Alexander B. Knierim, Deva Krupakar Kusuluri, Katherine Leon, Ines Liebscher, Xianhua Piao, Simone PrömelNicole Scholz, Swati Srivastava, Doreen Thor, Kimberley F. Tolias, Yuri A. Ushkaryov, Mario Vallon, Erwin G. Van Meir, Benoit Vanhollebeke, Uwe Wolfrum, Kevin M. Wright, Kelly R. Monk, Amit Mogha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
PublisherBlackwell Publishing Inc.
Pages5-25
Number of pages21
Edition1
DOIs
StatePublished - 2019

Publication series

NameAnnals of the New York Academy of Sciences
Number1
Volume1456
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Adhesion G protein
  • Cancer
  • Coupled receptor
  • Development
  • Immunology
  • Mechanosensation
  • Neurobiology
  • Signal transduction
  • Structural biology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Morgan, R. K., Anderson, G. R., Araç, D., Aust, G., Balenga, N., Boucard, A., Bridges, J. P., Engel, F. B., Formstone, C. J., Glitsch, M. D., Gray, R. S., Hall, R. A., Hsiao, C. C., Kim, H. Y., Knierim, A. B., Kusuluri, D. K., Leon, K., Liebscher, I., Piao, X., ... Mogha, A. (2019). The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors. In Annals of the New York Academy of Sciences (1 ed., pp. 5-25). (Annals of the New York Academy of Sciences; Vol. 1456, No. 1). Blackwell Publishing Inc.. https://doi.org/10.1111/nyas.14094