The evidence for fungus in Crohn’s disease pathogenesis

Jun Miyoshi, Mark (Anthony) Sofia, Joseph Francis Pierre

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Current evidence suggests the etiology of inflammatory bowel diseases (IBD) involves the confluence of host genetic, environmental, and microbial factors that lead to chronic, and often refractory, disease in susceptible individuals. The involvement of microbial triggers in IBD, including Crohn’s disease (CD), is increasingly evident with supporting data provided with advancements in metagenomic sequencing that have identified perturbations in microbial structure and function—broadly termed dysbiosis—in CD patients compared with healthy subjects. This concept is supported by the finding germ-free animals with CD genetic susceptibility fail to develop disease; demonstrating microorganisms are necessary but not sufficient for CD. The vast majority of CD microbiome research has focused on the complex bacterial communities and microbiome dysbiosis in the gut with 16S metagenomic sequencing. However, emerging data capturing eukaryotes suggest fungal opportunistic pathogens are also associated with IBD pathogenesis and chronicity. This hypothesis is further supported by historical observations that CD patient populations display elevated antibodies against fungal targets, even evident before disease diagnosis. This review discusses the current findings in the field, followed by historical and metagenomic evidence for fungal pathogens in the development and recurrence of CD in adult and pediatric populations.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalClinical Journal of Gastroenterology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

Crohn Disease
Fungi
Metagenomics
Inflammatory Bowel Diseases
Microbiota
Fungal Antibodies
Microbial Genetics
Dysbiosis
Disease Susceptibility
Genetic Predisposition to Disease
Eukaryota
Population
Healthy Volunteers
Pediatrics
Recurrence
Research

Keywords

  • Crohn’s disease
  • Fungal pathogens
  • Inflammatory bowel diseases
  • Microbiome
  • Mycobiome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The evidence for fungus in Crohn’s disease pathogenesis. / Miyoshi, Jun; Sofia, Mark (Anthony); Pierre, Joseph Francis.

In: Clinical Journal of Gastroenterology, Vol. 11, No. 6, 01.12.2018, p. 449-456.

Research output: Contribution to journalReview article

Miyoshi, Jun ; Sofia, Mark (Anthony) ; Pierre, Joseph Francis. / The evidence for fungus in Crohn’s disease pathogenesis. In: Clinical Journal of Gastroenterology. 2018 ; Vol. 11, No. 6. pp. 449-456.
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