The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours

Kun Hu, Frank A J L Scheer, Ruud M. Buijs, Steven Shea

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Heartbeat fluctuations in mammals display a robust temporal structure characterized by scale-invariant/fractal patterns. These scale-invariant patterns likely confer physiological advantage because they change with cardiovascular disease and these changes are associated with reduced survival. Models of physical systems imply that to produce scale-invariant patterns, factors influencing the system at different time scales must be coupled via a network of feedback interactions. A similar cardiac control network is hypothesized to be responsible for the scale-invariant pattern in heartbeat dynamics, although the essential network components have not been determined. Here is shown that scale-invariant cardiac control occurs across time scales from minutes to ∼24 h, and that lesioning the mammalian circadian pacemaker (suprachiasmatic nucleus; SCN) completely abolishes the scale-invariant pattern at time scales >∼4 h. At time scales

Original languageEnglish (US)
Pages (from-to)265-273
Number of pages9
JournalJournal of Biological Rhythms
Volume23
Issue number3
DOIs
StatePublished - Jun 2008
Externally publishedYes

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physical models
cardiovascular diseases
heart rate
Heart Rate
mammals
Fractals
Suprachiasmatic Nucleus
Mammals
Cardiovascular Diseases

Keywords

  • Cardiac control
  • Feedback interactions
  • Network
  • Scale-invariant patterns
  • SCN lesion
  • The suprachiasmatic nucleus (SCN)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology
  • Physiology (medical)

Cite this

The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. / Hu, Kun; Scheer, Frank A J L; Buijs, Ruud M.; Shea, Steven.

In: Journal of Biological Rhythms, Vol. 23, No. 3, 06.2008, p. 265-273.

Research output: Contribution to journalArticle

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