The emerging role of the RAB25 small GTPase in cancer

Roshan Agarwal, Igor Jurisica, Gordon B. Mills, Kwai Wa Cheng

    Research output: Contribution to journalReview article

    61 Scopus citations

    Abstract

    RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness. Variations in structure and post-translational modifications control the localization of RAS superfamily proteins to specific subcellular compartments and recruitment of downstream effectors, allowing these small GTPases to function as sophisticated modulators of a complex and diverse range of cellular processes. Here, we review the link between RAB25 and tumor development and current knowledge regarding its possible roles in cancer.

    Original languageEnglish (US)
    Pages (from-to)1561-1568
    Number of pages8
    JournalTraffic
    Volume10
    Issue number11
    DOIs
    StatePublished - Nov 2009

    Keywords

    • Breast
    • CATX-8
    • Cancer
    • Endocytosis
    • Ovarian
    • Rab25
    • Small GTPases

    ASJC Scopus subject areas

    • Structural Biology
    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cell Biology

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