The emerging role of lysophosphatidic acid in cancer

Gordon Mills, Wouter H. Moolenaar

Research output: Contribution to journalReview article

823 Citations (Scopus)

Abstract

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

Original languageEnglish (US)
Pages (from-to)582-591
Number of pages10
JournalNature Reviews Cancer
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Lysophosphatidic Acid Receptors
Neoplasms
G-Protein-Coupled Receptors
Cell Movement
Phospholipids
Cell Survival
Cell Proliferation
Neoplasm Metastasis
Enzymes
lysophosphatidic acid
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

The emerging role of lysophosphatidic acid in cancer. / Mills, Gordon; Moolenaar, Wouter H.

In: Nature Reviews Cancer, Vol. 3, No. 8, 01.08.2003, p. 582-591.

Research output: Contribution to journalReview article

Mills, Gordon ; Moolenaar, Wouter H. / The emerging role of lysophosphatidic acid in cancer. In: Nature Reviews Cancer. 2003 ; Vol. 3, No. 8. pp. 582-591.
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