The emerging role of lysophosphatidic acid in cancer

Gordon B. Mills, Wouter H. Moolenaar

    Research output: Contribution to journalReview article

    838 Scopus citations


    The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

    Original languageEnglish (US)
    Pages (from-to)582-591
    Number of pages10
    JournalNature Reviews Cancer
    Issue number8
    StatePublished - Aug 1 2003

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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