The effects of vasopressin injection on uterine artery blood flow during dilation and evacuation

Julie T. Crawford, Alison Edelman, Leonardo Pereira, Paula Bednarek, John Buckmaster

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: This study was undertaken to determine whether vasopressin decreases uterine artery blood flow and blood loss in early second-trimester surgical abortions (dilation and evacuation). Study Design: Randomized, double blind, placebo-controlled trial of a saline paracervical block with or without vasopressin before dilation and evacuation. Uterine artery pulsatility index and blood loss were measured. Results: Demographics were similar in both groups (mean gestational age 16.8 weeks, SD 1.7). Of 35 randomly assigned patients, Doppler waveforms were adequate in 28 patients (vasopressin, n = 13; placebo, n = 15). The mean difference in uterine artery pulsatility index before and after injection between groups was not significantly different (P = .14). Procedural blood loss was no different. Conclusion: Paracervical vasopressin compared to placebo injection did not result in significant changes in uterine artery pulsatility index in early second-trimester dilation and evacuation procedures.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Uterine Artery
Vasopressins
Dilatation
Injections
Placebos
Second Pregnancy Trimester
Obstetrical Anesthesia
Gestational Age
Demography

Keywords

  • abortion
  • Doppler ultrasound
  • uterine artery
  • vasopressin

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

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title = "The effects of vasopressin injection on uterine artery blood flow during dilation and evacuation",
abstract = "Objective: This study was undertaken to determine whether vasopressin decreases uterine artery blood flow and blood loss in early second-trimester surgical abortions (dilation and evacuation). Study Design: Randomized, double blind, placebo-controlled trial of a saline paracervical block with or without vasopressin before dilation and evacuation. Uterine artery pulsatility index and blood loss were measured. Results: Demographics were similar in both groups (mean gestational age 16.8 weeks, SD 1.7). Of 35 randomly assigned patients, Doppler waveforms were adequate in 28 patients (vasopressin, n = 13; placebo, n = 15). The mean difference in uterine artery pulsatility index before and after injection between groups was not significantly different (P = .14). Procedural blood loss was no different. Conclusion: Paracervical vasopressin compared to placebo injection did not result in significant changes in uterine artery pulsatility index in early second-trimester dilation and evacuation procedures.",
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T1 - The effects of vasopressin injection on uterine artery blood flow during dilation and evacuation

AU - Crawford, Julie T.

AU - Edelman, Alison

AU - Pereira, Leonardo

AU - Bednarek, Paula

AU - Buckmaster, John

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N2 - Objective: This study was undertaken to determine whether vasopressin decreases uterine artery blood flow and blood loss in early second-trimester surgical abortions (dilation and evacuation). Study Design: Randomized, double blind, placebo-controlled trial of a saline paracervical block with or without vasopressin before dilation and evacuation. Uterine artery pulsatility index and blood loss were measured. Results: Demographics were similar in both groups (mean gestational age 16.8 weeks, SD 1.7). Of 35 randomly assigned patients, Doppler waveforms were adequate in 28 patients (vasopressin, n = 13; placebo, n = 15). The mean difference in uterine artery pulsatility index before and after injection between groups was not significantly different (P = .14). Procedural blood loss was no different. Conclusion: Paracervical vasopressin compared to placebo injection did not result in significant changes in uterine artery pulsatility index in early second-trimester dilation and evacuation procedures.

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