The Effects of Topical S(+)-Ibuprofen on Interleukin-1 Induced Ocular Inflammation in a Rabbit Model

Morris E. Tilden, Richard S. Boney, James T. Rosenbaum, Marvin M. Goldenberg

Research output: Contribution to journalArticle

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Abstract

Topical non-steroidal anti-inflammatory drugs may serve as an alternative or adjunct to topical corticosteroid therapy for iritis. We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha. Topically administered S(+)-ibuprofen was found to inhibit increased vascular permeability associated with this model. These results with topical S(+)-ibuprofen compare favorably to the results seen with topical prednisolone and are significantly superior to the results seen with topical flurbiprofen. Topical S(+)-ibuprofen did not significantly reduce the cellular infiltration associated with interleukin-1 induced inflammation. These findings suggest a potential role for topical S(+)-ibuprofen in the treatment of ocular inflammation and, in this animal model, it appears to be superior to an alternative non-steroidal compound, but further studies are indicated to assess its activity in alternate models of ocular inflammation.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalJournal of Ocular Pharmacology
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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