The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model

M. E. Tilden, R. S. Boney, James (Jim) Rosenbaum, J. T. Rosenbaum

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Topical non-steroidal anti-inflammatory drugs may serve as an alternative or adjunct to topical corticosteroid therapy for iritis. We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha. Topically administered S(+)-ibuprofen was found to inhibit increased vascular permeability associated with this model. These results with topical S(+)-ibuprofen compare favorably to the results seen with topical prednisolone and are significantly superior to the results seen with topical flurbiprofen. Topical S(+)-ibuprofen did not significantly reduce the cellular infiltration associated with interleukin-1 induced inflammation. These findings suggest a potential role for topical S(+)-ibuprofen in the treatment of ocular inflammation and, in this animal model, it appears to be superior to an alternative non-steroidal compound, but further studies are indicated to assess its activity in alternate models of ocular inflammation.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalJournal of Ocular Pharmacology
Volume6
Issue number2
StatePublished - 1990

Fingerprint

Ibuprofen
Interleukin-1
Rabbits
Inflammation
Iritis
Flurbiprofen
Intravitreal Injections
Interleukin-1alpha
Uveitis
Capillary Permeability
Prednisolone
Adrenal Cortex Hormones
Anti-Inflammatory Agents
Animal Models
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model. / Tilden, M. E.; Boney, R. S.; Rosenbaum, James (Jim); Rosenbaum, J. T.

In: Journal of Ocular Pharmacology, Vol. 6, No. 2, 1990, p. 131-135.

Research output: Contribution to journalArticle

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