TY - JOUR
T1 - The effects of timolol maleate and acetazolamide on the rate of aqueous formation in normal human subjects
AU - Dailey, Roger A.
AU - Brubaker, Richard F.
AU - Bourne, William M.
N1 - Funding Information:
From the Department of Ophthalmology, Mayo Clinic and Foundation, Rochester, Minnesota. This study was supported in part by grants EY00634 (Dr. Bourne) and EY02037 (Dr. Brubaker) from the National Institutes of Health and by grants from Research to Prevent Blindness, Inc., and the Mayo Foundation.
PY - 1982/2
Y1 - 1982/2
N2 - We used a double-masked, randomized, placebo-controlled study of the effect of acetazolamide alone and timolol maleate alone and of the two in combination on the rate of aqueous humor flow in 21 normal subjects. The rate of aqueous flow was measured by fluorophotometry over an eight-hour period. Timolol decreased the flow by 33%, acetazolamide by 27%, and the drug combination by 44%, compared to the placebo treated eye (P<.01). Timolol produced a 26% decrease in intraocular pressure. Timolol decreased the intraocular pressure in the fellow eye by 16%, acetazolamide by 21%, and the two drugs together by 35% (P<.01). Neither drug significantly affected the anterior chamber volume, the endothelium's permeability, or the estimated endothelial pump rate.
AB - We used a double-masked, randomized, placebo-controlled study of the effect of acetazolamide alone and timolol maleate alone and of the two in combination on the rate of aqueous humor flow in 21 normal subjects. The rate of aqueous flow was measured by fluorophotometry over an eight-hour period. Timolol decreased the flow by 33%, acetazolamide by 27%, and the drug combination by 44%, compared to the placebo treated eye (P<.01). Timolol produced a 26% decrease in intraocular pressure. Timolol decreased the intraocular pressure in the fellow eye by 16%, acetazolamide by 21%, and the two drugs together by 35% (P<.01). Neither drug significantly affected the anterior chamber volume, the endothelium's permeability, or the estimated endothelial pump rate.
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U2 - 10.1016/0002-9394(82)90419-6
DO - 10.1016/0002-9394(82)90419-6
M3 - Article
C2 - 7039328
AN - SCOPUS:0020067083
SN - 0002-9394
VL - 93
SP - 232
EP - 237
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -