The effects of sex steroids on ulnar growth during adolescence

F. G. Cassorla, M. C. Skerda, I. M. Valk, W. Hung, G. B. Cutler, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

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Abstract

To investigate the relative effects of androgens and estrogens on long bone growth, we evaluated the 3-week ulnar growth velocities of 10 boys before and after the iv administration of testosterone (T; 15 mg/day), dihydrotestosterone (DHT; 7 mg/day), and estradiol (E2; 90 μg/day) for 4 days. Ulnar growth is a sensitive index of short term growth in children. Mean 3-week ulnar growth velocities increased from 0.49 ± 0.11 (±SEM) to 1.09 ± 0.14 mm/3 weeks after the T infusion (P <0.005), from 0.42 ± 0.09 to 0.84 ± 0.13 mm/3 weeks after the DHT infusion (P <0.02), and from 0.67 ± 0.07 to 0.96 ± 0.26 mm/3 weeks after the E2 infusion (P = NS). The mean T level was 2555 ± 234 ng/dl during the T infusion. Mean E2 levels were 53 ± 4 pg/ml during the T infusion and 102 ± 7 pg/ml during the E2 infusion. Mean DHT levels were 73 ± 7 ng/dl during the T infusion and 1115 ± 124 ng/dl during the DHT infusion. Mean somatomedin-C levels increased to a similar degree during all infusions, but were significantly higher only during the E2 infusion (P <0.01). We conclude that T and DHT given for 4 days stimulated ulnar growth, while E2 at concentrations greater than those derived from T did not cause a significant increase in ulnar growth. None of the ulnar growth rates after T, DHT, or E2 treatment, however, differed significantly.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume58
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Steroids
Growth
Dihydrotestosterone
Bone Development
Insulin-Like Growth Factor I
Androgens
Testosterone
Estradiol
Bone
Estrogens
Scanning electron microscopy
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Cassorla, F. G., Skerda, M. C., Valk, I. M., Hung, W., Cutler, G. B., & Loriaux, D. L. (1984). The effects of sex steroids on ulnar growth during adolescence. Journal of Clinical Endocrinology and Metabolism, 58(4), 717-720.

The effects of sex steroids on ulnar growth during adolescence. / Cassorla, F. G.; Skerda, M. C.; Valk, I. M.; Hung, W.; Cutler, G. B.; Loriaux, Donald (Lynn).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 58, No. 4, 1984, p. 717-720.

Research output: Contribution to journalArticle

Cassorla, FG, Skerda, MC, Valk, IM, Hung, W, Cutler, GB & Loriaux, DL 1984, 'The effects of sex steroids on ulnar growth during adolescence', Journal of Clinical Endocrinology and Metabolism, vol. 58, no. 4, pp. 717-720.
Cassorla, F. G. ; Skerda, M. C. ; Valk, I. M. ; Hung, W. ; Cutler, G. B. ; Loriaux, Donald (Lynn). / The effects of sex steroids on ulnar growth during adolescence. In: Journal of Clinical Endocrinology and Metabolism. 1984 ; Vol. 58, No. 4. pp. 717-720.
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