The effects of pre-enucleation irradiation on the development of metastases from intraocular greene melanoma in hamsters

George A. Fournier, Amanda M. Saulenas, Johanna M. Seddon, Michael Goitein, Daniel M. Albert, Lela Polivogianis, Evangelos Gragoudas

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Using intraocular Greene melanoma in a hamster model, we studied the effect of pre-enucleation irradiation on the development of melanoma metastases. One group (No. = 111) was treated with 1,210 to 1,600 rads of cobaltous chloride Co 60 gamma irradiation before enucleation and the second group (No. = 100) received no irradiation. The groups did not differ with respect to presence of metastases in the 106 days after tumor implantation (χ2 = 3.05; P = .08). However, Kaplan-Meier survival curves gave a longer time to melanoma-related death in the irradiated animals compared with the controls (log rank test, P = .0008).

Original languageEnglish (US)
Pages (from-to)669-677
Number of pages9
JournalAmerican journal of ophthalmology
Volume100
Issue number5
DOIs
StatePublished - Nov 15 1985

ASJC Scopus subject areas

  • Ophthalmology

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