The effects of ovariectomy on the responsiveness of preoptic - septal neurons to microelectrophoresed estrogen

M. J. Kelly; R. L. Moss; C. A. Dudley

doi:10.1159/000122742

The effects of ovariectomy on the responsiveness of preoptic - septal neurons to microelectrophoresed estrogen

M. J. Kelly, R. L. Moss, C. A. Dudley

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Extracellular potentials were recorded from medial preoptic-septal (MPOA-S) neurons in 2-week and 3-4 month ovariectomized rats, and the effects of microelectrophoresed 17β-estradiol hemisuccinate (17βE₂S), acetylcholine (Ach), cortisol hemisuccinate (CS) and glutamate (Glut) were studied, 17βE₂S failed to produce changes in the firing rate of the majority of MPOA-S neurons tested, but Ach excited 48% of these neurons. MPOA-S neurons showed very little response to either Glut or CS. Previous findings from this laboratory have demonstrated that MPOA-S neurons recorded in 4-day cyclic female rats will respond to 17βE₂S. Therefore the present results suggest that the ovarian steroids are necessary for maintaining this electrical sensitivity. Also, the involvement of a specific membrane or cytoplasmic receptor is discussed.

Original language	English (US)
Pages (from-to)	204-211
Number of pages	8
Journal	Neuroendocrinology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1159/000122742
State	Published - Jan 1 1978
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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title = "The effects of ovariectomy on the responsiveness of preoptic - septal neurons to microelectrophoresed estrogen",

abstract = "Extracellular potentials were recorded from medial preoptic-septal (MPOA-S) neurons in 2-week and 3-4 month ovariectomized rats, and the effects of microelectrophoresed 17β-estradiol hemisuccinate (17βE2S), acetylcholine (Ach), cortisol hemisuccinate (CS) and glutamate (Glut) were studied, 17βE2S failed to produce changes in the firing rate of the majority of MPOA-S neurons tested, but Ach excited 48% of these neurons. MPOA-S neurons showed very little response to either Glut or CS. Previous findings from this laboratory have demonstrated that MPOA-S neurons recorded in 4-day cyclic female rats will respond to 17βE2S. Therefore the present results suggest that the ovarian steroids are necessary for maintaining this electrical sensitivity. Also, the involvement of a specific membrane or cytoplasmic receptor is discussed.",

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AU - Moss, R. L.

AU - Dudley, C. A.

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N2 - Extracellular potentials were recorded from medial preoptic-septal (MPOA-S) neurons in 2-week and 3-4 month ovariectomized rats, and the effects of microelectrophoresed 17β-estradiol hemisuccinate (17βE2S), acetylcholine (Ach), cortisol hemisuccinate (CS) and glutamate (Glut) were studied, 17βE2S failed to produce changes in the firing rate of the majority of MPOA-S neurons tested, but Ach excited 48% of these neurons. MPOA-S neurons showed very little response to either Glut or CS. Previous findings from this laboratory have demonstrated that MPOA-S neurons recorded in 4-day cyclic female rats will respond to 17βE2S. Therefore the present results suggest that the ovarian steroids are necessary for maintaining this electrical sensitivity. Also, the involvement of a specific membrane or cytoplasmic receptor is discussed.

AB - Extracellular potentials were recorded from medial preoptic-septal (MPOA-S) neurons in 2-week and 3-4 month ovariectomized rats, and the effects of microelectrophoresed 17β-estradiol hemisuccinate (17βE2S), acetylcholine (Ach), cortisol hemisuccinate (CS) and glutamate (Glut) were studied, 17βE2S failed to produce changes in the firing rate of the majority of MPOA-S neurons tested, but Ach excited 48% of these neurons. MPOA-S neurons showed very little response to either Glut or CS. Previous findings from this laboratory have demonstrated that MPOA-S neurons recorded in 4-day cyclic female rats will respond to 17βE2S. Therefore the present results suggest that the ovarian steroids are necessary for maintaining this electrical sensitivity. Also, the involvement of a specific membrane or cytoplasmic receptor is discussed.

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The effects of ovariectomy on the responsiveness of preoptic - septal neurons to microelectrophoresed estrogen

Abstract

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