The effects of N,N-diethyl-4-methyl-3-Oxo-4-Aza-5α-androstane-17β-carb oxamide, a 5α-reductase inhibitor and antiandrogen, on the development of baldness in the stumptail macaque

R. S. Rittmaster, H. Uno, M. L. Povar, T. N. Mellin, Donald (Lynn) Loriaux

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Abstract

We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5α-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-MA-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-MA-treated group [46 ± 6 (±SE) vs. 48 ± 4], while a significant decrease occurred in the control group (63 ± 6 vs. 25 ± 12; P <0.025). Skin 5α-reductase activity was reduced in the scalp of the 4-MA-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgen-dependent baldness.

Original languageEnglish (US)
Pages (from-to)188-193
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume65
Issue number1
Publication statusPublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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