We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5α-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-Mα-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-Mα-treated group [46 ± 6 (±se) vs. 48 ± 4], while a significant decrease occurred in the control group (63 ± 6 vs. 25 ± 12; P < 0.025). Skin 5α-reductase activity was reduced in the scalp of the 4-Mα-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgendependent baldness.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical