The effects of n, n-diethyl-4-methyl-3-oxo-4-azα-5α-androstane-17yβ-carboxamide, a 5α-reductase inhibitor and antiandrogen, on the development of baldness in the stumptail macaque

Roger S. Rittmaster, Hideo Uno, Morris L. Povar, Theodore N. Mellin, D. Lynn Loriaux

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5α-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-Mα-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-Mα-treated group [46 ± 6 (±se) vs. 48 ± 4], while a significant decrease occurred in the control group (63 ± 6 vs. 25 ± 12; P < 0.025). Skin 5α-reductase activity was reduced in the scalp of the 4-Mα-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgendependent baldness.

Original languageEnglish (US)
Pages (from-to)188-193
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume65
Issue number1
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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