TY - JOUR

T1 - The effects of measurement error in response variables and tests of association of explanatory variables in change models

AU - Yanez, N. David

AU - Kronmal, Richard A.

AU - Shemanski, Lynn R.

PY - 1998/11/30

Y1 - 1998/11/30

N2 - Biomedical studies often measure variables with error. Examples in the literature include investigation of the association between the change in some outcome variable (blood pressure, cholesterol level etc.) and a set of explanatory variables (age, smoking status etc.). Typically, one fits linear regression models to investigate such associations. With the outcome variable measured with error, a problem occurs when we include the baseline value of the outcome variable as a covariate. In such instances, one can find a relationship between the observed change in the outcome and the explanatory variables even when there is no association between these variables and the true change in the outcome variable. We present a simple method of adjusting for a common measurement error bias that tends to be overlooked in the modelling of associations with change. Additional information (for example, replicates, instrumental variables) is needed to estimate the variance of the measurement error to perform this bias correction.

AB - Biomedical studies often measure variables with error. Examples in the literature include investigation of the association between the change in some outcome variable (blood pressure, cholesterol level etc.) and a set of explanatory variables (age, smoking status etc.). Typically, one fits linear regression models to investigate such associations. With the outcome variable measured with error, a problem occurs when we include the baseline value of the outcome variable as a covariate. In such instances, one can find a relationship between the observed change in the outcome and the explanatory variables even when there is no association between these variables and the true change in the outcome variable. We present a simple method of adjusting for a common measurement error bias that tends to be overlooked in the modelling of associations with change. Additional information (for example, replicates, instrumental variables) is needed to estimate the variance of the measurement error to perform this bias correction.

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U2 - 10.1002/(SICI)1097-0258(19981130)17:22<2597::AID-SIM940>3.0.CO;2-G

DO - 10.1002/(SICI)1097-0258(19981130)17:22<2597::AID-SIM940>3.0.CO;2-G

M3 - Article

C2 - 9839350

AN - SCOPUS:0032583151

VL - 17

SP - 2597

EP - 2606

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 22

ER -