The effects of in vitro target compression modulus on laser thrombolytic ablation rate

Abram D. Janis, Sean J. Kirkpatrick, Kenton W. Gregory, Scott A. Prahl

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 μsec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (μg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.

Original languageEnglish (US)
Pages (from-to)419-429
Number of pages11
JournalProceedings of SPIE-The International Society for Optical Engineering
Volume4609
DOIs
StatePublished - Jan 1 2002

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Keywords

  • Ablation efficiency
  • Clot model
  • Laser thrombolysis
  • Stroke

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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