The effects of in vitro target compression modulus on laser thrombolytic ablation rate

Abram D. Janis, Sean J. Kirkpatrick, Kenton Gregory, Scott A. Prahl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 μsec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (μg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsW.T.W. Riese, K.E. Bartels, L.S. Bass, K.W. Gregory
Pages419-429
Number of pages11
Volume4609
DOIs
StatePublished - 2002
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII - San Jose, CA, United States
Duration: Jan 19 2002Jan 22 2002

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
CountryUnited States
CitySan Jose, CA
Period1/19/021/22/02

Fingerprint

Laser ablation
laser ablation
gelatins
Lasers
lasers
Dye lasers
Hemoglobin
hemoglobin
strokes
Pulsed lasers
dye lasers
blood
Laser pulses
therapy
repetition
pulsed lasers
Blood
Dyes
dyes
pulses

Keywords

  • Ablation efficiency
  • Clot model
  • Laser thrombolysis
  • Stroke

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Janis, A. D., Kirkpatrick, S. J., Gregory, K., & Prahl, S. A. (2002). The effects of in vitro target compression modulus on laser thrombolytic ablation rate. In W. T. W. Riese, K. E. Bartels, L. S. Bass, & K. W. Gregory (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4609, pp. 419-429) https://doi.org/10.1117/12.441250

The effects of in vitro target compression modulus on laser thrombolytic ablation rate. / Janis, Abram D.; Kirkpatrick, Sean J.; Gregory, Kenton; Prahl, Scott A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / W.T.W. Riese; K.E. Bartels; L.S. Bass; K.W. Gregory. Vol. 4609 2002. p. 419-429.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Janis, AD, Kirkpatrick, SJ, Gregory, K & Prahl, SA 2002, The effects of in vitro target compression modulus on laser thrombolytic ablation rate. in WTW Riese, KE Bartels, LS Bass & KW Gregory (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4609, pp. 419-429, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, San Jose, CA, United States, 1/19/02. https://doi.org/10.1117/12.441250
Janis AD, Kirkpatrick SJ, Gregory K, Prahl SA. The effects of in vitro target compression modulus on laser thrombolytic ablation rate. In Riese WTW, Bartels KE, Bass LS, Gregory KW, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4609. 2002. p. 419-429 https://doi.org/10.1117/12.441250
Janis, Abram D. ; Kirkpatrick, Sean J. ; Gregory, Kenton ; Prahl, Scott A. / The effects of in vitro target compression modulus on laser thrombolytic ablation rate. Proceedings of SPIE - The International Society for Optical Engineering. editor / W.T.W. Riese ; K.E. Bartels ; L.S. Bass ; K.W. Gregory. Vol. 4609 2002. pp. 419-429
@inproceedings{37869f590d50416ba4d53caea6292127,
title = "The effects of in vitro target compression modulus on laser thrombolytic ablation rate",
abstract = "Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 μsec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (μg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.",
keywords = "Ablation efficiency, Clot model, Laser thrombolysis, Stroke",
author = "Janis, {Abram D.} and Kirkpatrick, {Sean J.} and Kenton Gregory and Prahl, {Scott A.}",
year = "2002",
doi = "10.1117/12.441250",
language = "English (US)",
volume = "4609",
pages = "419--429",
editor = "W.T.W. Riese and K.E. Bartels and L.S. Bass and K.W. Gregory",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - The effects of in vitro target compression modulus on laser thrombolytic ablation rate

AU - Janis, Abram D.

AU - Kirkpatrick, Sean J.

AU - Gregory, Kenton

AU - Prahl, Scott A.

PY - 2002

Y1 - 2002

N2 - Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 μsec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (μg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.

AB - Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 μsec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (μg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.

KW - Ablation efficiency

KW - Clot model

KW - Laser thrombolysis

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0036403457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036403457&partnerID=8YFLogxK

U2 - 10.1117/12.441250

DO - 10.1117/12.441250

M3 - Conference contribution

AN - SCOPUS:0036403457

VL - 4609

SP - 419

EP - 429

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Riese, W.T.W.

A2 - Bartels, K.E.

A2 - Bass, L.S.

A2 - Gregory, K.W.

ER -