The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes

M. R. Malinow, F. J. Nieto, W. D. Kruger, P. B. Duell, D. L. Hess, R. A. Gluckman, P. C. Block, C. R. Holzgang, P. H. Anderson, D. Seltzer, B. Upson, Q. R. Lin

Research output: Contribution to journalArticle

249 Scopus citations

Abstract

Elevated concentration of plasma total homocysteine (tHcy) is a common risk factor for arterial occlusive diseases. Folio acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction. We tested the effects of a 3-week daily intake of 1 or 2 mg of FA supplements on tHcy levels in patients with and without coronary heart disease (CHD) who were analyzed for the C677T MTHFR mutation. Prior multivitamin intake and baseline vitamin and they levels were also compared with responsiveness to folate supplementation. Both dosages of FA lowered they levels similarly, regardless of sex, age, CHD status, body mass index, smoking, or plasma creatinine concentration. In non-multivitamin users, FA supplements reduced tHcy by 7% in C/C homozygotes and by 13% or 21% in subjects with one or two copies of the T677 allele, respectively; the corresponding reductions were smaller in users of multivitamins. Moreover, T/T homozygotes had elevated they and increased susceptibility to high levels of tHcy at marginally low plasma folate levels, as well as enhanced response to the tHcy-lowering effects of FA. Although other factors are probably involved in the responsiveness of tHcy levels to FA supplementation, about one third of heterogeneity in responsiveness was attributable to baseline tHcy and folate levels and to multivitamin use.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume17
Issue number6
DOIs
StatePublished - Jan 1 1997

Keywords

  • Arterial occlusive diseases
  • Gene mutations
  • Homocyst(e)ine
  • Vitamin therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Malinow, M. R., Nieto, F. J., Kruger, W. D., Duell, P. B., Hess, D. L., Gluckman, R. A., Block, P. C., Holzgang, C. R., Anderson, P. H., Seltzer, D., Upson, B., & Lin, Q. R. (1997). The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arteriosclerosis, thrombosis, and vascular biology, 17(6), 1157-1162. https://doi.org/10.1161/01.ATV.17.6.1157