The effects of ethanol on glial cell proliferation: relevance to the fetal alcohol syndrome.

Marina Guizzetti, M. Catlin, L. G. Costa

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Exposure to ethanol during pregnancy is detrimental to brain development. Individuals affected by the Fetal Alcohol Syndrome present a number of central nervous system dysfunctions including microencephaly and mental retardation. Studies on the mechanisms of ethanol's developmental neurotoxicity have focused on its interaction with neurons; however, emerging evidence is suggesting that ethanol can significantly affect glial cells as well. A number of in vitro studies have shown that ethanol can inhibit the proliferation of various glial cells (mostly primary astrocytes or astrocytoma cells) at relatively high concentrations (100-200 mM). On the other hand, proliferation induced by some, but not all mitogens, is inhibited by low concentrations (10-50 mM) of ethanol. These inhibitory effects of ethanol may contribute to its developmental neurotoxicity observed following in vivo exposure. Animal models have indeed shown that ethanol causes microencephaly when given during the brain growth spurt, a period of brain development characterized by astroglial proliferation and maturation.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume2
StatePublished - 1997
Externally publishedYes

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Fetal Alcohol Spectrum Disorders
Cell proliferation
Neuroglia
Ethanol
Alcohols
Cell Proliferation
Brain
Astrocytoma
Neurology
Mitogens
Astrocytes
Intellectual Disability
Neurons
Animals
Central Nervous System
Animal Models
Pregnancy
Growth

Cite this

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abstract = "Exposure to ethanol during pregnancy is detrimental to brain development. Individuals affected by the Fetal Alcohol Syndrome present a number of central nervous system dysfunctions including microencephaly and mental retardation. Studies on the mechanisms of ethanol's developmental neurotoxicity have focused on its interaction with neurons; however, emerging evidence is suggesting that ethanol can significantly affect glial cells as well. A number of in vitro studies have shown that ethanol can inhibit the proliferation of various glial cells (mostly primary astrocytes or astrocytoma cells) at relatively high concentrations (100-200 mM). On the other hand, proliferation induced by some, but not all mitogens, is inhibited by low concentrations (10-50 mM) of ethanol. These inhibitory effects of ethanol may contribute to its developmental neurotoxicity observed following in vivo exposure. Animal models have indeed shown that ethanol causes microencephaly when given during the brain growth spurt, a period of brain development characterized by astroglial proliferation and maturation.",
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AU - Guizzetti, Marina

AU - Catlin, M.

AU - Costa, L. G.

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