The effects of ephedrine and etilefrine on uterine and fetal blood flow and on fetal myocardial function during spinal anaesthesia for caesarean section

Juha Rasanen, S. Alahuhta, T. Kangas-Saarela, R. Jouppila, P. Jouppila

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effects of two vasopressors, ephedrine and etilefrine, on blood flow in maternal uterine, fetal umbilical, middle cerebral and renal arteries and on fetal myocardial function were studied by colour Doppler and M-mode echocardiography techniques during spinal anaesthesia for caesarean section. There were 7 healthy pregnant women in each treatment group. The vascular resistance of maternal uterine arteries increased significantly after both of the vasopressors while the vascular resistance of the umbilical artery remained unchanged. Ephedrine decreased the blood velocity waveform indices in the fetal middle cerebral and renal arteries, increased fetal right ventricular contractility and decreased left ventricular inner end-diastolic dimension. Fetal heart rate was unchanged. Etilefrine caused no detectable changes in fetal haemodynamics or in fetal myocardial function. These findings demonstrate that vasopressors administered for the treatment of minor maternal arterial pressure fall produce vasoconstriction in the uterine circulation during spinal anaesthesia, yet healthy fetuses seem to tolerate these haemodynamic alterations well. On the other hand, ephedrine caused changes in fetal myocardial function and in the vascular resistance of fetal middle cerebral and renal arteries, which demonstrates the potential modifying effect of vasoactive drug given to the mother on fetal haemodynamics.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalInternational Journal of Obstetric Anesthesia
Volume1
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Etilefrine
Ephedrine
Spinal Anesthesia
Fetal Blood
Cesarean Section
Middle Cerebral Artery
Renal Artery
Mothers
Vascular Resistance
Hemodynamics
Umbilicus
Uterine Artery
Fetal Heart Rate
Umbilical Arteries
Vasoconstriction
Echocardiography
Pregnant Women
Arterial Pressure
Fetus
Color

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Psychology(all)

Cite this

The effects of ephedrine and etilefrine on uterine and fetal blood flow and on fetal myocardial function during spinal anaesthesia for caesarean section. / Rasanen, Juha; Alahuhta, S.; Kangas-Saarela, T.; Jouppila, R.; Jouppila, P.

In: International Journal of Obstetric Anesthesia, Vol. 1, No. 1, 1991, p. 3-8.

Research output: Contribution to journalArticle

@article{b567b69184184aaaa0d1c16caddd1951,
title = "The effects of ephedrine and etilefrine on uterine and fetal blood flow and on fetal myocardial function during spinal anaesthesia for caesarean section",
abstract = "The effects of two vasopressors, ephedrine and etilefrine, on blood flow in maternal uterine, fetal umbilical, middle cerebral and renal arteries and on fetal myocardial function were studied by colour Doppler and M-mode echocardiography techniques during spinal anaesthesia for caesarean section. There were 7 healthy pregnant women in each treatment group. The vascular resistance of maternal uterine arteries increased significantly after both of the vasopressors while the vascular resistance of the umbilical artery remained unchanged. Ephedrine decreased the blood velocity waveform indices in the fetal middle cerebral and renal arteries, increased fetal right ventricular contractility and decreased left ventricular inner end-diastolic dimension. Fetal heart rate was unchanged. Etilefrine caused no detectable changes in fetal haemodynamics or in fetal myocardial function. These findings demonstrate that vasopressors administered for the treatment of minor maternal arterial pressure fall produce vasoconstriction in the uterine circulation during spinal anaesthesia, yet healthy fetuses seem to tolerate these haemodynamic alterations well. On the other hand, ephedrine caused changes in fetal myocardial function and in the vascular resistance of fetal middle cerebral and renal arteries, which demonstrates the potential modifying effect of vasoactive drug given to the mother on fetal haemodynamics.",
author = "Juha Rasanen and S. Alahuhta and T. Kangas-Saarela and R. Jouppila and P. Jouppila",
year = "1991",
doi = "10.1016/0959-289X(91)90022-I",
language = "English (US)",
volume = "1",
pages = "3--8",
journal = "International Journal of Obstetric Anesthesia",
issn = "0959-289X",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - The effects of ephedrine and etilefrine on uterine and fetal blood flow and on fetal myocardial function during spinal anaesthesia for caesarean section

AU - Rasanen, Juha

AU - Alahuhta, S.

AU - Kangas-Saarela, T.

AU - Jouppila, R.

AU - Jouppila, P.

PY - 1991

Y1 - 1991

N2 - The effects of two vasopressors, ephedrine and etilefrine, on blood flow in maternal uterine, fetal umbilical, middle cerebral and renal arteries and on fetal myocardial function were studied by colour Doppler and M-mode echocardiography techniques during spinal anaesthesia for caesarean section. There were 7 healthy pregnant women in each treatment group. The vascular resistance of maternal uterine arteries increased significantly after both of the vasopressors while the vascular resistance of the umbilical artery remained unchanged. Ephedrine decreased the blood velocity waveform indices in the fetal middle cerebral and renal arteries, increased fetal right ventricular contractility and decreased left ventricular inner end-diastolic dimension. Fetal heart rate was unchanged. Etilefrine caused no detectable changes in fetal haemodynamics or in fetal myocardial function. These findings demonstrate that vasopressors administered for the treatment of minor maternal arterial pressure fall produce vasoconstriction in the uterine circulation during spinal anaesthesia, yet healthy fetuses seem to tolerate these haemodynamic alterations well. On the other hand, ephedrine caused changes in fetal myocardial function and in the vascular resistance of fetal middle cerebral and renal arteries, which demonstrates the potential modifying effect of vasoactive drug given to the mother on fetal haemodynamics.

AB - The effects of two vasopressors, ephedrine and etilefrine, on blood flow in maternal uterine, fetal umbilical, middle cerebral and renal arteries and on fetal myocardial function were studied by colour Doppler and M-mode echocardiography techniques during spinal anaesthesia for caesarean section. There were 7 healthy pregnant women in each treatment group. The vascular resistance of maternal uterine arteries increased significantly after both of the vasopressors while the vascular resistance of the umbilical artery remained unchanged. Ephedrine decreased the blood velocity waveform indices in the fetal middle cerebral and renal arteries, increased fetal right ventricular contractility and decreased left ventricular inner end-diastolic dimension. Fetal heart rate was unchanged. Etilefrine caused no detectable changes in fetal haemodynamics or in fetal myocardial function. These findings demonstrate that vasopressors administered for the treatment of minor maternal arterial pressure fall produce vasoconstriction in the uterine circulation during spinal anaesthesia, yet healthy fetuses seem to tolerate these haemodynamic alterations well. On the other hand, ephedrine caused changes in fetal myocardial function and in the vascular resistance of fetal middle cerebral and renal arteries, which demonstrates the potential modifying effect of vasoactive drug given to the mother on fetal haemodynamics.

UR - http://www.scopus.com/inward/record.url?scp=0002877963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002877963&partnerID=8YFLogxK

U2 - 10.1016/0959-289X(91)90022-I

DO - 10.1016/0959-289X(91)90022-I

M3 - Article

VL - 1

SP - 3

EP - 8

JO - International Journal of Obstetric Anesthesia

JF - International Journal of Obstetric Anesthesia

SN - 0959-289X

IS - 1

ER -