The effects of endoscopic sinus surgery on level of fatigue in patients with chronic rhinosinusitis

Nathan Sautter, Jess Mace, Alexander C. Chester, Timothy Smith

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Fatigue is a common symptom of chronic rhinosinusitis (CRS), but the response of fatigue to endoscopic sinus surgery (ESS) is rarely studied. Methods: A prospective, open cohort of adult patients undergoing ESS for CRS was studied using 10-cm fatigue visual analog scales (VASs), Lund-MacKay computed tomography (CT), and Lund-Kennedy nasal endoscopy scoring. Results: Two hundred seventy-two patients, followed for a mean (±SD) of 16.5 ± 8.5 months after ESS, noted significant fatigue improvement with an effect size defined as large by Cohen (0.8 [95% CI, 0.5-1.3]). Neither preoperative CT scores nor preoperative endoscopy scores correlated with preoperative fatigue severity. Compared with the mean preoperative fatigue score (6.1 ± 2.9 cm), preoperative fatigue was more severe in women (6.9 ± 2.6 cm; p <0.001) patients with depression (7.7 ± 2.4 cm; p <0.001) and patients with fibromyalgia (7.9 ± 2.2 cm; p = 0.013), but less severe in patients with nasal polyposis (5.4 ± 3.2 cm; p = 0.009). Significantly greater postoperative reduction in fatigue was noted in patients with fibromyalgia when compared with study patients without fibromyalgia (effect size = 1.8 [95% CI, 1.6-2.2]; p > 0.001) with final fatigue severity scores similar to the entire study group. Similarly, patients with severe fatigue (n = 112; mean VAS score, 8.8 ± 0.8 cm) showed a more pronounced improvement than patients less severely fatigued (n = 160; mean VAS score 4.2 ± 2.4 cm; effect size = 2.2 [95% CI, 2.0-2.9]; p > 0.001). Conclusion: Fatigue improves after ESS, with significantly greater improvement in patients with fibromyalgia and in patients that are more severely fatigued at presentation.

Original languageEnglish (US)
Pages (from-to)420-426
Number of pages7
JournalAmerican Journal of Rhinology
Volume22
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Fatigue
Visual Analog Scale
Endoscopy
Tomography
Fibromyalgia
Nose

Keywords

  • Chronic rhinosinusitis
  • Endoscopic
  • Endoscopic sinus surgery
  • Fatigue
  • Fibromyalgia
  • Lund-MacKay
  • Outcomes
  • Quality of life
  • Sinusitis
  • Visual analog scales

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

The effects of endoscopic sinus surgery on level of fatigue in patients with chronic rhinosinusitis. / Sautter, Nathan; Mace, Jess; Chester, Alexander C.; Smith, Timothy.

In: American Journal of Rhinology, Vol. 22, No. 4, 07.2008, p. 420-426.

Research output: Contribution to journalArticle

Sautter, Nathan ; Mace, Jess ; Chester, Alexander C. ; Smith, Timothy. / The effects of endoscopic sinus surgery on level of fatigue in patients with chronic rhinosinusitis. In: American Journal of Rhinology. 2008 ; Vol. 22, No. 4. pp. 420-426.
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abstract = "Background: Fatigue is a common symptom of chronic rhinosinusitis (CRS), but the response of fatigue to endoscopic sinus surgery (ESS) is rarely studied. Methods: A prospective, open cohort of adult patients undergoing ESS for CRS was studied using 10-cm fatigue visual analog scales (VASs), Lund-MacKay computed tomography (CT), and Lund-Kennedy nasal endoscopy scoring. Results: Two hundred seventy-two patients, followed for a mean (±SD) of 16.5 ± 8.5 months after ESS, noted significant fatigue improvement with an effect size defined as large by Cohen (0.8 [95{\%} CI, 0.5-1.3]). Neither preoperative CT scores nor preoperative endoscopy scores correlated with preoperative fatigue severity. Compared with the mean preoperative fatigue score (6.1 ± 2.9 cm), preoperative fatigue was more severe in women (6.9 ± 2.6 cm; p <0.001) patients with depression (7.7 ± 2.4 cm; p <0.001) and patients with fibromyalgia (7.9 ± 2.2 cm; p = 0.013), but less severe in patients with nasal polyposis (5.4 ± 3.2 cm; p = 0.009). Significantly greater postoperative reduction in fatigue was noted in patients with fibromyalgia when compared with study patients without fibromyalgia (effect size = 1.8 [95{\%} CI, 1.6-2.2]; p > 0.001) with final fatigue severity scores similar to the entire study group. Similarly, patients with severe fatigue (n = 112; mean VAS score, 8.8 ± 0.8 cm) showed a more pronounced improvement than patients less severely fatigued (n = 160; mean VAS score 4.2 ± 2.4 cm; effect size = 2.2 [95{\%} CI, 2.0-2.9]; p > 0.001). Conclusion: Fatigue improves after ESS, with significantly greater improvement in patients with fibromyalgia and in patients that are more severely fatigued at presentation.",
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N2 - Background: Fatigue is a common symptom of chronic rhinosinusitis (CRS), but the response of fatigue to endoscopic sinus surgery (ESS) is rarely studied. Methods: A prospective, open cohort of adult patients undergoing ESS for CRS was studied using 10-cm fatigue visual analog scales (VASs), Lund-MacKay computed tomography (CT), and Lund-Kennedy nasal endoscopy scoring. Results: Two hundred seventy-two patients, followed for a mean (±SD) of 16.5 ± 8.5 months after ESS, noted significant fatigue improvement with an effect size defined as large by Cohen (0.8 [95% CI, 0.5-1.3]). Neither preoperative CT scores nor preoperative endoscopy scores correlated with preoperative fatigue severity. Compared with the mean preoperative fatigue score (6.1 ± 2.9 cm), preoperative fatigue was more severe in women (6.9 ± 2.6 cm; p <0.001) patients with depression (7.7 ± 2.4 cm; p <0.001) and patients with fibromyalgia (7.9 ± 2.2 cm; p = 0.013), but less severe in patients with nasal polyposis (5.4 ± 3.2 cm; p = 0.009). Significantly greater postoperative reduction in fatigue was noted in patients with fibromyalgia when compared with study patients without fibromyalgia (effect size = 1.8 [95% CI, 1.6-2.2]; p > 0.001) with final fatigue severity scores similar to the entire study group. Similarly, patients with severe fatigue (n = 112; mean VAS score, 8.8 ± 0.8 cm) showed a more pronounced improvement than patients less severely fatigued (n = 160; mean VAS score 4.2 ± 2.4 cm; effect size = 2.2 [95% CI, 2.0-2.9]; p > 0.001). Conclusion: Fatigue improves after ESS, with significantly greater improvement in patients with fibromyalgia and in patients that are more severely fatigued at presentation.

AB - Background: Fatigue is a common symptom of chronic rhinosinusitis (CRS), but the response of fatigue to endoscopic sinus surgery (ESS) is rarely studied. Methods: A prospective, open cohort of adult patients undergoing ESS for CRS was studied using 10-cm fatigue visual analog scales (VASs), Lund-MacKay computed tomography (CT), and Lund-Kennedy nasal endoscopy scoring. Results: Two hundred seventy-two patients, followed for a mean (±SD) of 16.5 ± 8.5 months after ESS, noted significant fatigue improvement with an effect size defined as large by Cohen (0.8 [95% CI, 0.5-1.3]). Neither preoperative CT scores nor preoperative endoscopy scores correlated with preoperative fatigue severity. Compared with the mean preoperative fatigue score (6.1 ± 2.9 cm), preoperative fatigue was more severe in women (6.9 ± 2.6 cm; p <0.001) patients with depression (7.7 ± 2.4 cm; p <0.001) and patients with fibromyalgia (7.9 ± 2.2 cm; p = 0.013), but less severe in patients with nasal polyposis (5.4 ± 3.2 cm; p = 0.009). Significantly greater postoperative reduction in fatigue was noted in patients with fibromyalgia when compared with study patients without fibromyalgia (effect size = 1.8 [95% CI, 1.6-2.2]; p > 0.001) with final fatigue severity scores similar to the entire study group. Similarly, patients with severe fatigue (n = 112; mean VAS score, 8.8 ± 0.8 cm) showed a more pronounced improvement than patients less severely fatigued (n = 160; mean VAS score 4.2 ± 2.4 cm; effect size = 2.2 [95% CI, 2.0-2.9]; p > 0.001). Conclusion: Fatigue improves after ESS, with significantly greater improvement in patients with fibromyalgia and in patients that are more severely fatigued at presentation.

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