The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat

Kim A. Neve, John F. Marshall

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [3H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalNeuroscience Letters
Volume46
Issue number1
DOIs
StatePublished - Apr 20 1984

Keywords

  • [H]spiroperidol
  • denervation
  • dopamine receptors
  • haloperidol
  • neostriatum
  • rat
  • receptor proliferation
  • supersensitivity

ASJC Scopus subject areas

  • Neuroscience(all)

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