The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomdlgus macaques: Dose response of cortisol secretion

H. M. Schulte; G. P. Chrousos; E. H. Oldfield; P. W. Gold; G. B. Cutler; D. L. Loriaux

doi:10.1210/jcem-55-4-810

The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomdlgus macaques: Dose response of cortisol secretion

H. M. Schulte, G. P. Chrousos, E. H. Oldfield, P. W. Gold, G. B. Cutler, D. L. Loriaux

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The recent identification of ovine corticotropin releasing factor (CRF), a 41-amino acid peptide, provides a potential new approach to evaluate disorders of the hypothalamic-pituitary-vadrenal axis. We report here the effects of this new factor in the pituitary stalk-sectioned cynomolgus macaque. Given as an intravenous bolus, CRF stimulated cortisol secretion with an ED₅₀ between 0.1 and 1 μg/kg body weight. The peak cortisol response occurred after 15-30 min at low doses (0.5 - 1 μg/kg) and after 45-90 min at higher doses (2-40 μg/kg). This factor also stimulated the release of growth hormone and prolactin, but had no effect on TSH or LH secretion.

Original language	English (US)
Pages (from-to)	810-812
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	55
Issue number	4
DOIs	https://doi.org/10.1210/jcem-55-4-810
State	Published - Oct 1982
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-55-4-810

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The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomdlgus macaques: Dose response of cortisol secretion. / Schulte, H. M.; Chrousos, G. P.; Oldfield, E. H. et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 4, 10.1982, p. 810-812.

Research output: Contribution to journal › Article › peer-review

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The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomdlgus macaques: Dose response of cortisol secretion

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