The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomolgus macaques: Dose response of cortisol secretion

H. M. Schulte, G. P. Chrousos, E. H. Oldfield, P. W. Gold, G. B. Cutler, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The recent identification of ovine corticotropin releasing factor (CRF), a 41-amino acid peptide, provides a potential new approach to evaluate disorders of the hypothalamic-pituitary-adrenal axis. We report here the effects of this new factor in the pituitary stalk-sectioned cynomolgus macaque. Given as an intravenous bolus, CRF stimulated cortisol secretion with an ED 50 between 0.1 and 1 μg/kg body weight. The peak cortisol response occurred after 15-30 min at low doses (0.5-1 μg/kg) and after 45-90 min at higher doses (2-40 μg/kg). This factor also stimulated the release of growth hormone and prolactin, but had no effect on TSH or LH secretion.

Original languageEnglish (US)
Pages (from-to)810-812
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number4
StatePublished - 1982
Externally publishedYes

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Corticotropin-Releasing Hormone
Macaca
Pituitary Gland
Hydrocortisone
Pituitary Diseases
Prolactin
Growth Hormone
Sheep
Body Weight
Amino Acids
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomolgus macaques : Dose response of cortisol secretion. / Schulte, H. M.; Chrousos, G. P.; Oldfield, E. H.; Gold, P. W.; Cutler, G. B.; Loriaux, Donald (Lynn).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 4, 1982, p. 810-812.

Research output: Contribution to journalArticle

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