The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomdlgus macaques: Dose response of cortisol secretion

H. M. Schulte, G. P. Chrousos, E. H. Oldfield, P. W. Gold, G. B. Cutler, D. L. Loriaux

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The recent identification of ovine corticotropin releasing factor (CRF), a 41-amino acid peptide, provides a potential new approach to evaluate disorders of the hypothalamic-pituitary-vadrenal axis. We report here the effects of this new factor in the pituitary stalk-sectioned cynomolgus macaque. Given as an intravenous bolus, CRF stimulated cortisol secretion with an ED50 between 0.1 and 1 μg/kg body weight. The peak cortisol response occurred after 15-30 min at low doses (0.5 - 1 μg/kg) and after 45-90 min at higher doses (2-40 μg/kg). This factor also stimulated the release of growth hormone and prolactin, but had no effect on TSH or LH secretion.

Original languageEnglish (US)
Pages (from-to)810-812
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number4
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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