The effects of anaemia as a programming agent in the fetal heart

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The intrauterine environment plays a powerful role in determining the life-long risk of cardiovascular disease. A number of stressors are well known to affect the development of the cardiovascular system in utero including over/under maternal nutrition, excess glucocorticoid and chronic hypoxia. Chronic fetal anaemia in sheep is a complex stressor that alters cardiac loading conditions, causes hypoxic stress and stimulates large changes in flow to specific tissues, including large increases in resting coronary blood flow and conductance. Decreased viscosity can account for approximately half of the increased flow. It appears that immature hearts are 'plastic' in that increases in coronary conductance with fetal anaemia persist into adulthood even if the anaemia is corrected before birth. These large changes in conductance are possible only through extensive remodelling of the coronary tree. Adult hearts that were once anaemic in utero are more resistant to hypoxic stress as adults but it is not known whether such an adaptation would be deleterious in later life. These studies indicate the need for investigation into the basic mechanisms of coronary tree remodelling in the immature myocardium. New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalJournal of Physiology
Volume565
Issue number1
DOIs
StatePublished - May 15 2005

Fingerprint

Fetal Heart
Anemia
Cardiovascular System
Viscosity
Glucocorticoids
Plastics
Coronary Disease
Sheep
Myocardium
Cardiovascular Diseases
Mothers
Parturition
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

The effects of anaemia as a programming agent in the fetal heart. / Davis, Lowell; Thornburg, Kent; Giraud, George.

In: Journal of Physiology, Vol. 565, No. 1, 15.05.2005, p. 35-41.

Research output: Contribution to journalArticle

@article{a6b52b51b08b4057b6302b91e8ce7cf7,
title = "The effects of anaemia as a programming agent in the fetal heart",
abstract = "The intrauterine environment plays a powerful role in determining the life-long risk of cardiovascular disease. A number of stressors are well known to affect the development of the cardiovascular system in utero including over/under maternal nutrition, excess glucocorticoid and chronic hypoxia. Chronic fetal anaemia in sheep is a complex stressor that alters cardiac loading conditions, causes hypoxic stress and stimulates large changes in flow to specific tissues, including large increases in resting coronary blood flow and conductance. Decreased viscosity can account for approximately half of the increased flow. It appears that immature hearts are 'plastic' in that increases in coronary conductance with fetal anaemia persist into adulthood even if the anaemia is corrected before birth. These large changes in conductance are possible only through extensive remodelling of the coronary tree. Adult hearts that were once anaemic in utero are more resistant to hypoxic stress as adults but it is not known whether such an adaptation would be deleterious in later life. These studies indicate the need for investigation into the basic mechanisms of coronary tree remodelling in the immature myocardium. New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease.",
author = "Lowell Davis and Kent Thornburg and George Giraud",
year = "2005",
month = "5",
day = "15",
doi = "10.1113/jphysiol.2004.082388",
language = "English (US)",
volume = "565",
pages = "35--41",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The effects of anaemia as a programming agent in the fetal heart

AU - Davis, Lowell

AU - Thornburg, Kent

AU - Giraud, George

PY - 2005/5/15

Y1 - 2005/5/15

N2 - The intrauterine environment plays a powerful role in determining the life-long risk of cardiovascular disease. A number of stressors are well known to affect the development of the cardiovascular system in utero including over/under maternal nutrition, excess glucocorticoid and chronic hypoxia. Chronic fetal anaemia in sheep is a complex stressor that alters cardiac loading conditions, causes hypoxic stress and stimulates large changes in flow to specific tissues, including large increases in resting coronary blood flow and conductance. Decreased viscosity can account for approximately half of the increased flow. It appears that immature hearts are 'plastic' in that increases in coronary conductance with fetal anaemia persist into adulthood even if the anaemia is corrected before birth. These large changes in conductance are possible only through extensive remodelling of the coronary tree. Adult hearts that were once anaemic in utero are more resistant to hypoxic stress as adults but it is not known whether such an adaptation would be deleterious in later life. These studies indicate the need for investigation into the basic mechanisms of coronary tree remodelling in the immature myocardium. New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease.

AB - The intrauterine environment plays a powerful role in determining the life-long risk of cardiovascular disease. A number of stressors are well known to affect the development of the cardiovascular system in utero including over/under maternal nutrition, excess glucocorticoid and chronic hypoxia. Chronic fetal anaemia in sheep is a complex stressor that alters cardiac loading conditions, causes hypoxic stress and stimulates large changes in flow to specific tissues, including large increases in resting coronary blood flow and conductance. Decreased viscosity can account for approximately half of the increased flow. It appears that immature hearts are 'plastic' in that increases in coronary conductance with fetal anaemia persist into adulthood even if the anaemia is corrected before birth. These large changes in conductance are possible only through extensive remodelling of the coronary tree. Adult hearts that were once anaemic in utero are more resistant to hypoxic stress as adults but it is not known whether such an adaptation would be deleterious in later life. These studies indicate the need for investigation into the basic mechanisms of coronary tree remodelling in the immature myocardium. New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease.

UR - http://www.scopus.com/inward/record.url?scp=19444375439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19444375439&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.2004.082388

DO - 10.1113/jphysiol.2004.082388

M3 - Article

C2 - 15760943

AN - SCOPUS:19444375439

VL - 565

SP - 35

EP - 41

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 1

ER -