The effect of ventilation, age, and asthmatic condition on ultrafine particle deposition in children

Hector A. Olvera, Daniel Perez, Juan W. Clague, Yung Sung Cheng, Wen Whai Li, Maria A. Amaya, Scott W. Burchiel, Marianne Berwick, Nicholas E. Pingitore

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Ultrafine particles (UFPs) contribute to health risks associated with air pollution, especially respiratory disease in children. Nonetheless, experimental data on UFP deposition in asthmatic children has been minimal. In this study, the effect of ventilation, developing respiratory physiology, and asthmatic condition on the deposition efficiency of ultrafine particles in children was explored. Deposited fractions of UFP (10200nm) were determined in 9 asthmatic children, 8 nonasthmatic children, and 5 nonasthmatic adults. Deposition efficiencies in adults served as reference of fully developed respiratory physiologies. A validated deposition model was employed as an auxiliary tool to assess the independent effect of varying ventilation on deposition. Asthmatic conditions were confirmed via pre-and post-bronchodilator spirometry. Subjects were exposed to a hygroscopic aerosol with number geometric mean diameter of 2731nm, geometric standard deviation of 1.82.0, and concentration of 1.2 × 106 particles cm-3. Exposure was through a silicone mouthpiece. Total deposited fraction (TDF) and normalized deposition rate were 50 and 32 higher in children than in adults. Accounting for tidal volume and age variation, TDF was 21 higher in asthmatic than in non-asthmatic children. The higher health risks of air pollution exposure observed in children and asthmatics might be augmented by their susceptibility to higher dosages of UFP.

Original languageEnglish (US)
Article number736290
JournalPulmonary Medicine
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'The effect of ventilation, age, and asthmatic condition on ultrafine particle deposition in children'. Together they form a unique fingerprint.

Cite this