TY - JOUR
T1 - The Effect of Tissue Expansion on Previously Irradiated Skin
AU - Kane, William J.
AU - Mccaffrey, Thomas V.
AU - Wang, Thomas D.
AU - Koval, Thomas M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1992/4
Y1 - 1992/4
N2 - Opinion remains divided over the advisability of tissue expansion in previously irradiated skin. We examined the properties of, and complications associated with, tissue expansion in previously irradiated rabbit scalps. Irradiation injury was produced using fractionated roentgen rays, with a total dose of 5000 cGy over a 5-week interval. Following a 20-week convalescence interval, expansion was incrementally conducted over 4 weeks. Monitored parameters included cutaneous perfusion as indicated by fiberoptic dermofluorometry, intraluminal pressure, linear surface gain, and area of surface necrosis. The incidence and severity of complications, including surface necrosis, were significantly higher among irradiated animals. Furthermore, the overlying skin of irradiated animals demonstrated a significantly decreased compliance and measurable area gain. Given the inferior expandability and higher tendency toward complications with contemporary expansion techniques in previously irradiated skin, alternate reconstructive options are preferable in this setting. (Arch Otolaryngol Head Neck Surg. 1992;118:419-426).
AB - Opinion remains divided over the advisability of tissue expansion in previously irradiated skin. We examined the properties of, and complications associated with, tissue expansion in previously irradiated rabbit scalps. Irradiation injury was produced using fractionated roentgen rays, with a total dose of 5000 cGy over a 5-week interval. Following a 20-week convalescence interval, expansion was incrementally conducted over 4 weeks. Monitored parameters included cutaneous perfusion as indicated by fiberoptic dermofluorometry, intraluminal pressure, linear surface gain, and area of surface necrosis. The incidence and severity of complications, including surface necrosis, were significantly higher among irradiated animals. Furthermore, the overlying skin of irradiated animals demonstrated a significantly decreased compliance and measurable area gain. Given the inferior expandability and higher tendency toward complications with contemporary expansion techniques in previously irradiated skin, alternate reconstructive options are preferable in this setting. (Arch Otolaryngol Head Neck Surg. 1992;118:419-426).
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U2 - 10.1001/archotol.1992.01880040085014
DO - 10.1001/archotol.1992.01880040085014
M3 - Article
C2 - 1554473
AN - SCOPUS:0026576620
SN - 0886-4470
VL - 118
SP - 419
EP - 426
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 4
ER -