The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs

Raymond H. Menard, D. Lynn Loriaux, Frederic C. Bartter, James R. Gillette

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The effect of the administration of spironolactone, deacetylspironolactone, aldadiene or soldactone on the concentration of plasma testosterone, estradiol, and cortisol was examined in male dogs. Decreases of 60 to 75% in plasma testosterone and estradiol occur only at high doses (100 mg/kg) of spironolactone or deacetylspironolactone but not at low doses of spironolactone (5 to 10 mg/kg); they occur concomitantly with similar decreases of androgen formation by the testis. No decreases were detected with aldadiene or soldactone. Treatment of dogs with spironolactone (100 mg/kg) also lowered by 50 to 65% the concentration of cortisol in adrenal venous plasma.

Original languageEnglish (US)
Pages (from-to)771-782
Number of pages12
JournalSteroids
Volume31
Issue number6
DOIs
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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