The effect of surgical stress on haemodynamics during neurolept anaesthesia

J. Santesson, Per-Olof Järnberg, S. Arner

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The influence of surgical stress on hemodynamics during neurolept anesthesia (NLA) was studied in 10 patients, while they were awake, under anesthesia prior to surgery and peroperatively. Systemic arterial, pulmonary arterial, right atrial and pulmonary capillary wedge pressures, as well as cardiac output (Q̇T), arterial oxygen content and mixed venous oxygen content, were measured. Systemic and pulmonary vascular resistances, arterial-venous oxygen content difference (AVD), oxygen consumption (V̇O2) and cardiac index (CI) were calculated. On institution of anesthesia, CI fell from 2.8 ± 0.1 l/min x m2 to 2.5 ± 0.2 l/min x m2 and systolic arterial pressure (SBP) fell from 13.4 ± 0.5 kPa to 10.2 ± 0.3 kPa. During surgery CI rose to 3.3 ± 0.1 l/min x m2 and SBP rose to 15.7 ± 0.6 kPa. Prior to anesthesia, AVD was 40.2 ± 0.2 ml/l. Under anesthesia prior to surgery, AVD did not change, but V̇O2 declined from 207 ± 13 ml/min to 171 ± 10 ml/min. During surgery, AVD fell to 30.5 ± 0.3 ml/l, while V̇O2 remained unchanged. It is concluded that NLA has a direct metabolic depressant effect and, in association with surgery, is accompanied by hyperkinetic circulation.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Issue number2
Publication statusPublished - 1978
Externally publishedYes


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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