The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure

Diana S. Woodruff-Pak, John T. Green, Jonathan Pak, Boris Heifets, Michelle H. Pak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the effect of several doses of scopolamine in older rabbits that were trained for 20 days in the 750 ms delay eyeblink classical conditioning procedure. Our aim was to determine if the scopolamine-injected older rabbit would be a useful model for testing drugs for cognition enhancement in Alzheimer's disease (AD). A total of 39 rabbits with a mean age of 31 months received classical eyeblink conditioning with daily injections of 0.25, 0.75, or 1.5 mg/kg scopolamine hydrobromide or sterile saline vehicle. Doses of 0.75 and 1.5 mg/kg scopolamine significantly impaired acquisition, whereas acquisition was not significantly impaired with 0.25 mg/kg scopolamine. Results exhibit parallels in performance on delay eyeblink classical conditioning between scopolamine-treated older rabbits and human patients diagnosed with AD.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalIntegrative Physiological and Behavioral Science
Volume37
Issue number2
StatePublished - Apr 2002
Externally publishedYes

Fingerprint

Classical Conditioning
Scopolamine Hydrobromide
conditioning
Rabbits
dementia
cognition
Alzheimer Disease
Testing
drug
Cognition
performance
Rabbit
Injections
Pharmaceutical Preparations
Dose
Alzheimer's Disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure. / Woodruff-Pak, Diana S.; Green, John T.; Pak, Jonathan; Heifets, Boris; Pak, Michelle H.

In: Integrative Physiological and Behavioral Science, Vol. 37, No. 2, 04.2002, p. 103-113.

Research output: Contribution to journalArticle

Woodruff-Pak, Diana S. ; Green, John T. ; Pak, Jonathan ; Heifets, Boris ; Pak, Michelle H. / The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure. In: Integrative Physiological and Behavioral Science. 2002 ; Vol. 37, No. 2. pp. 103-113.
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