The Effect of Prostaglandin E2 and Indomethacin on the Placental Vascular Response to Norepinephrine

Anne Berssenbrugge, Debra Anderson, Terrance Phernetton, John H.G. Rankin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The vascular response to norepinephrine is expressed in terms of a resistance ratio which is defined as the ratio of the vascular resistance seen 1.5 min after norepinephrine administration to that seen before norepinephrine administration. The injection of 1 μg/kg of norepinephrine to near-term sheep significantly increased the vascular resistance of the placenta to a ratio of 2.27 ± 0.52 (mean ± SEM; N = 7). Pretreatment with 20 jug of prostaglandin E2 per minute significantly decreased the placental response to norepinephrine to a resistance ratio of 1.47 ± 0.21 which was 65% of the untreated response (N = 7). Pretreatment with 10 mg/kg indomethacin significantly increased the placental response to norepinephrine from a resistance ratio of 2.25 ± 0.70 to 2.71 ± 0.84, which is 120% of the untreated value (N = 6). Prostaglandin E2 attenuated the placental vascular response to norepinephrine and indomethacin potentiated this response.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume159
Issue number2
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Dinoprostone
Indomethacin
Blood Vessels
Norepinephrine
Vascular Resistance
Placenta
Sheep
Scanning electron microscopy
Injections

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Effect of Prostaglandin E2 and Indomethacin on the Placental Vascular Response to Norepinephrine. / Berssenbrugge, Anne; Anderson, Debra; Phernetton, Terrance; Rankin, John H.G.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 159, No. 2, 1978, p. 281-285.

Research output: Contribution to journalArticle

Berssenbrugge, Anne ; Anderson, Debra ; Phernetton, Terrance ; Rankin, John H.G. / The Effect of Prostaglandin E2 and Indomethacin on the Placental Vascular Response to Norepinephrine. In: Proceedings of the Society for Experimental Biology and Medicine. 1978 ; Vol. 159, No. 2. pp. 281-285.
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