The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass

Emily K. Ward; Dara P. Schuster; Katie H. Stowers; Amanda K. Royse; Diana Ir; Charles E. Robertson; Daniel N. Frank; Gregory L. Austin

doi:10.1007/s11695-014-1275-1

The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass

Emily K. Ward, Dara P. Schuster, Katie H. Stowers, Amanda K. Royse, Diana Ir, Charles E. Robertson, Daniel N. Frank, Gregory L. Austin

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p=nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p=0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.

Original language	English (US)
Pages (from-to)	1567-1571
Number of pages	5
Journal	Obesity Surgery
Volume	24
Issue number	9
DOIs	https://doi.org/10.1007/s11695-014-1275-1
State	Published - Sep 2014
Externally published	Yes

Keywords

Gastric bypass
Gut microbiota
PPI
Severe obesity

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Access to Document

10.1007/s11695-014-1275-1

Cite this

@article{3e85b8d6cafc4499b2674828c19e412c,

title = "The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass",

abstract = "Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p=nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p=0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.",

keywords = "Gastric bypass, Gut microbiota, PPI, Severe obesity",

author = "Ward, {Emily K.} and Schuster, {Dara P.} and Stowers, {Katie H.} and Royse, {Amanda K.} and Diana Ir and Robertson, {Charles E.} and Frank, {Daniel N.} and Austin, {Gregory L.}",

note = "Funding Information: Acknowledgments This project was supported by a grant from the Colorado Clinical Translational Science Institute Project Grant (5UL1RR025780).",

year = "2014",

month = sep,

doi = "10.1007/s11695-014-1275-1",

language = "English (US)",

volume = "24",

pages = "1567--1571",

journal = "Obesity Surgery",

issn = "0960-8923",

publisher = "Springer New York",

number = "9",

}

TY - JOUR

T1 - The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass

AU - Ward, Emily K.

AU - Schuster, Dara P.

AU - Stowers, Katie H.

AU - Royse, Amanda K.

AU - Ir, Diana

AU - Robertson, Charles E.

AU - Frank, Daniel N.

AU - Austin, Gregory L.

N1 - Funding Information: Acknowledgments This project was supported by a grant from the Colorado Clinical Translational Science Institute Project Grant (5UL1RR025780).

PY - 2014/9

Y1 - 2014/9

N2 - Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p=nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p=0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.

AB - Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p=nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p=0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.

KW - Gastric bypass

KW - Gut microbiota

KW - PPI

KW - Severe obesity

UR - http://www.scopus.com/inward/record.url?scp=84906279070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906279070&partnerID=8YFLogxK

U2 - 10.1007/s11695-014-1275-1

DO - 10.1007/s11695-014-1275-1

M3 - Article

C2 - 24849914

AN - SCOPUS:84906279070

SN - 0960-8923

VL - 24

SP - 1567

EP - 1571

JO - Obesity Surgery

JF - Obesity Surgery

IS - 9

ER -

The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this