The effect of pentoxifylline on cochlear blood flow

M. J. LaRouere; J. S. Sillman; M. T. Tsai; A. L. Nuttall

doi:10.1177/019459989210600133

The effect of pentoxifylline on cochlear blood flow

M. J. LaRouere, J. S. Sillman, M. T. Tsai, A. L. Nuttall

Otolaryngology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.

Original language	English (US)
Pages (from-to)	87-91
Number of pages	5
Journal	Otolaryngology - Head and Neck Surgery
Volume	106
Issue number	1
DOIs	https://doi.org/10.1177/019459989210600133
State	Published - Jan 1 1992

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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abstract = "Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.",

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