Abstract
Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 87-91 |
| Number of pages | 5 |
| Journal | Otolaryngology - Head and Neck Surgery |
| Volume | 106 |
| Issue number | 1 |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Otorhinolaryngology
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The effect of pentoxifylline on cochlear blood flow. / LaRouere, M. J.; Sillman, J. S.; Tsai, M. T.; Nuttall, Alfred.
In: Otolaryngology - Head and Neck Surgery, Vol. 106, No. 1, 1992, p. 87-91.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The effect of pentoxifylline on cochlear blood flow
AU - LaRouere, M. J.
AU - Sillman, J. S.
AU - Tsai, M. T.
AU - Nuttall, Alfred
PY - 1992
Y1 - 1992
N2 - Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.
AB - Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.
UR - http://www.scopus.com/inward/record.url?scp=0026513719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026513719&partnerID=8YFLogxK
M3 - Article
VL - 106
SP - 87
EP - 91
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
SN - 0194-5998
IS - 1
ER -