The Effect of Onset Age of Visual Deprivation on Visual Cortex Surface Area Across-Species

Adrian K. Andelin, Jaime F. Olavarria, Ione Fine, Erin N. Taber, Daniel Schwartz, Christopher (Chris) Kroenke, Alexander Stevens

Research output: Contribution to journalArticle

Abstract

Blindness early in life induces permanent alterations in brain anatomy, including reduced surface area of primary visual cortex (V1). Bilateral enucleation early in development causes greater reductions in primary visual cortex surface area than at later times. However, the time at which cortical surface area expansion is no longer sensitive to enucleation is not clearly established, despite being an important milestone for cortical development. Using histological and MRI techniques, we investigated how reductions in the surface area of V1 depends on the timing of blindness onset in rats, ferrets and humans. To compare data across species, we translated ages of all species to a common neuro-developmental event-time (ET) scale. Consistently, blindness during early cortical expansion induced large (~40%) reductions in V1 surface area, in rats and ferrets, while blindness occurring later had diminishing effects. Longitudinal measurements on ferrets confirmed that early enucleation disrupted cortical expansion, rather than inducing enhanced pruning. We modeled the ET associated with the conclusion of the effect of blindness on surface area at maturity (ETc), relative to the normal conclusion of visual cortex surface area expansion, (ETdev). A final analysis combining our data with extant published data confirmed that ETc occurred well before ETdev.

Original languageEnglish (US)
Pages (from-to)4321-4333
Number of pages13
JournalCerebral cortex (New York, N.Y. : 1991)
Volume29
Issue number10
DOIs
StatePublished - Sep 13 2019

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Visual Cortex
Blindness
Age of Onset
Ferrets
Histological Techniques
Anatomy
Brain

Keywords

  • blindness
  • cross-species
  • enucleation
  • surface area
  • visual cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The Effect of Onset Age of Visual Deprivation on Visual Cortex Surface Area Across-Species. / Andelin, Adrian K.; Olavarria, Jaime F.; Fine, Ione; Taber, Erin N.; Schwartz, Daniel; Kroenke, Christopher (Chris); Stevens, Alexander.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 29, No. 10, 13.09.2019, p. 4321-4333.

Research output: Contribution to journalArticle

Andelin, Adrian K. ; Olavarria, Jaime F. ; Fine, Ione ; Taber, Erin N. ; Schwartz, Daniel ; Kroenke, Christopher (Chris) ; Stevens, Alexander. / The Effect of Onset Age of Visual Deprivation on Visual Cortex Surface Area Across-Species. In: Cerebral cortex (New York, N.Y. : 1991). 2019 ; Vol. 29, No. 10. pp. 4321-4333.
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