The effect of luteinizing hormone releasing hormone (LHRH) antiserum administrationon gonadotropin secretion in the rhesus monkey

J. T. McCormack; T. M. Plant; D. L. Hess; E. Knobil

doi:10.1210/endo-100-3-663

The effect of luteinizing hormone releasing hormone (LHRH) antiserum administrationon gonadotropin secretion in the rhesus monkey

J. T. McCormack, T. M. Plant, D. L. Hess, E. Knobil

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentrations in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10–21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce onic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.

Original language	English (US)
Pages (from-to)	663-667
Number of pages	5
Journal	Endocrinology
Volume	100
Issue number	3
DOIs	https://doi.org/10.1210/endo-100-3-663
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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abstract = "Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentrations in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10–21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce onic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.",

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AU - Hess, D. L.

AU - Knobil, E.

PY - 1977

Y1 - 1977

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AB - Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentrations in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10–21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce onic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.

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The effect of luteinizing hormone releasing hormone (LHRH) antiserum administrationon gonadotropin secretion in the rhesus monkey

Abstract

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