The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey

J. T. McCormack, T. M. Plant, David Hess, E. Knobil

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentration in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10-21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce tonic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.

Original languageEnglish (US)
Pages (from-to)663-667
Number of pages5
JournalEndocrinology
Volume100
Issue number3
StatePublished - 1977
Externally publishedYes

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Macaca mulatta
Gonadotropins
Gonadotropin-Releasing Hormone
Immune Sera
Estrogens
Rabbits
Injections
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey. / McCormack, J. T.; Plant, T. M.; Hess, David; Knobil, E.

In: Endocrinology, Vol. 100, No. 3, 1977, p. 663-667.

Research output: Contribution to journalArticle

McCormack, J. T. ; Plant, T. M. ; Hess, David ; Knobil, E. / The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey. In: Endocrinology. 1977 ; Vol. 100, No. 3. pp. 663-667.
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