The effect of luteinizing hormone releasing hormone (LHRH) antiserum administrationon gonadotropin secretion in the rhesus monkey

J. T. McCormack, T. M. Plant, D. L. Hess, E. Knobil

    Research output: Contribution to journalArticle

    34 Scopus citations

    Abstract

    Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentrations in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10–21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce onic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.

    Original languageEnglish (US)
    Pages (from-to)663-667
    Number of pages5
    JournalEndocrinology
    Volume100
    Issue number3
    DOIs
    StatePublished - Jan 1 1977

    ASJC Scopus subject areas

    • Endocrinology

    Fingerprint Dive into the research topics of 'The effect of luteinizing hormone releasing hormone (LHRH) antiserum administrationon gonadotropin secretion in the rhesus monkey'. Together they form a unique fingerprint.

  • Cite this