The effect of late gestation foetal hypoglycaemia on cardiovascular and endocrine function in sheep

J. K. Cleal, Susan Bagby, M. A. Hanson, H. M. Gardiner, L. R. Green

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, for example, umbilical cord occlusion (UCO). We investigated the effect of low-circulating glucose on foetal CV control mechanisms and response to UCO. Under general anaesthesia, late gestation foetal sheep (n = 7, 119 days gestational age (dGA), term ∼147 days) were implanted with vascular catheters, a bladder catheter, electrocardiogram electrodes and an umbilical cord occluder. Mean arterial pressure (MAP), heart rate (HR) and kidney function were monitored during maternal saline (MSAL 125dGA) and insulin (MINS 126dGA) infusion, and foetal CV responses were assessed during incremental doses of angiotensin II, a 90-s total UCO, and administration of phenylephrine to assess baroreflex function. During MINS infusion, the decrease in maternal and foetal blood glucose was associated with a small but significant decrease in foetal HR and reduced foetal baroreflex sensitivity (P < 0.05). The increase in foetal MAP during a 90-s UCO was greater during hypoglycaemia (P < 0.05). The MAP response to angiotensin II was not affected by hypoglycaemia. Decreased foetal HR and baroreflex sensitivity and increased CV responsiveness to UCO during hypoglycaemia indicates altered CV homoestatic mechanisms. The combination of altered nutrition and a CV challenge, such as UCO, during late gestation may have a cumulative effect on foetal CV function.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalJournal of Developmental Origins of Health and Disease
Volume1
Issue number1
DOIs
StatePublished - 2010

Fingerprint

Umbilical Cord
Hypoglycemia
Sheep
Pregnancy
Baroreflex
Arterial Pressure
Fetal Heart Rate
Angiotensin II
Mothers
Vascular Access Devices
Phenylephrine
Fetal Blood
Growth and Development
General Anesthesia
Gestational Age
Blood Glucose
Electrocardiography
Electrodes
Urinary Bladder
Catheters

Keywords

  • cardiovascular
  • foetus
  • glucose

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

The effect of late gestation foetal hypoglycaemia on cardiovascular and endocrine function in sheep. / Cleal, J. K.; Bagby, Susan; Hanson, M. A.; Gardiner, H. M.; Green, L. R.

In: Journal of Developmental Origins of Health and Disease, Vol. 1, No. 1, 2010, p. 42-49.

Research output: Contribution to journalArticle

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