The effect of inhaled nitric oxide and inhaled iloprost on hypoxaemia in a patient with pulmonary hypertension after pulmonary thrombarterectomy

M. Flondor, Matthias Merkel, C. Hofstetter, M. Irlbeck, L. Frey, B. Zwissler

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Acute pulmonary hypertension with life-threatening right heart failure may complicate the postoperative course following cardiothoracic surgery. Both inhaled nitric oxide and inhaled iloprost, a stable analogue of prostacyclin, have been used frequently for this purpose in acute pulmonary hypertension of various origins. We present a case of a patient with acute pulmonary hypertension and severely impaired gas exchange following pulmonary thrombo-endarterectomy. Therapy with one inhaled vasodilator alone did not satisfactorily abort a postoperative pulmonary hypertensive crisis and low-output syndrome due to right heart failure. Combined inhaled nitric oxide and inhaled iloprost, however, showed additive effects. Hence, the combination of both drugs may be reasonable in cases where the standard therapy fails. The effect has been demonstrated by means of continuous blood gas monitoring.

Original languageEnglish (US)
Pages (from-to)1200-1203
Number of pages4
JournalAnaesthesia
Volume61
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Iloprost
Pulmonary Hypertension
Nitric Oxide
Lung
Heart Failure
Pulmonary Gas Exchange
Endarterectomy
Epoprostenol
Drug Combinations
Vasodilator Agents
Gases
Therapeutics
Hypoxia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effect of inhaled nitric oxide and inhaled iloprost on hypoxaemia in a patient with pulmonary hypertension after pulmonary thrombarterectomy. / Flondor, M.; Merkel, Matthias; Hofstetter, C.; Irlbeck, M.; Frey, L.; Zwissler, B.

In: Anaesthesia, Vol. 61, No. 12, 12.2006, p. 1200-1203.

Research output: Contribution to journalArticle

Flondor, M. ; Merkel, Matthias ; Hofstetter, C. ; Irlbeck, M. ; Frey, L. ; Zwissler, B. / The effect of inhaled nitric oxide and inhaled iloprost on hypoxaemia in a patient with pulmonary hypertension after pulmonary thrombarterectomy. In: Anaesthesia. 2006 ; Vol. 61, No. 12. pp. 1200-1203.
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