The effect of human cytomegalovirus on the production and biologic action of interleukin-1

Ashlee Moses, Helen M. Garnett

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of mycoplasma-free human cytomegalovirus (HCMV) on the production and biologic activity of interleukin-1 (IL-1) from peripheral blood monocytes was examined. The use of biologic thymocyte assays revealed a time-dependent decrease in the IL-1 activity of both HCMV-challenged and control monocytes after initiation of culture. A decrease in the amount of IL-1β secreted as measured by ELISA was also detected. The amount of IL-1β secreted by HCMV-challenged cells was always greater than that produced by control cultures at similar times. Despite containing higher levels of IL-17beta;, supernatants from challenged cells were markedly less effective in supporting thymocyte proliferation. It is proposed that this is due to the concomitant production of an inhibitor of IL-1 activity from HCMV-challenged monocyte cultures.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalJournal of Infectious Diseases
Volume162
Issue number2
StatePublished - Aug 1990
Externally publishedYes

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Cytomegalovirus
Interleukin-1
Monocytes
Thymocytes
Human Activities
Mycoplasma
Biological Assay
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The effect of human cytomegalovirus on the production and biologic action of interleukin-1. / Moses, Ashlee; Garnett, Helen M.

In: Journal of Infectious Diseases, Vol. 162, No. 2, 08.1990, p. 381-388.

Research output: Contribution to journalArticle

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