The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus

William L. Isley, William Harris, John M. Miles

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Statins improve all major lipid fractions, reduce coronary heart disease risk, and may have a minor effect on glucose tolerance. A reduction in free fatty acid flux and concentrations could be partly responsible for these effects. We measured nocturnal and postprandial plasma palmitate concentrations and rate of appearance (Ra) on 2 occasions in 12 obese dyslipidemic subjects with type 2 diabetes mellitus, using a single-blind, crossover format (placebo followed by simvastatin, 80 mg/d), and also on 1 occasion in 6 untreated control subjects. The diabetic subjects had increased average nocturnal (127 ± 13 vs 80 ± 10 μmol/L, P <.05) and 2-hour postprandial (49 ± 6 vs 17 ± 2 μmol/L, P <.001) palmitate concentrations, as well as increased nocturnal (31.6 ± 3.7 vs 19.5 ± 3.7 mmol/m2 over 9 hours, P <.05) and postprandial (11.5 ± 3.7 vs 5.5 ± 3.7 mmol/m2 every 4 hours, P <.005) integrated palmitate Ra compared to normal controls. High-dose simvastatin reduced serum triglycerides by 35% but had no effect on plasma palmitate concentrations or Ra. These results suggest that the triglyceride-lowering effect of statins is not mediated through an effect on FFA metabolism.

Original languageEnglish (US)
Pages (from-to)758-762
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume55
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

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Simvastatin
Palmitates
Nonesterified Fatty Acids
Type 2 Diabetes Mellitus
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Triglycerides
Coronary Disease
Placebos
Lipids
Glucose
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus. / Isley, William L.; Harris, William; Miles, John M.

In: Metabolism: Clinical and Experimental, Vol. 55, No. 6, 06.2006, p. 758-762.

Research output: Contribution to journalArticle

Isley, William L. ; Harris, William ; Miles, John M. / The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus. In: Metabolism: Clinical and Experimental. 2006 ; Vol. 55, No. 6. pp. 758-762.
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