The effect of golimumab on haemoglobin levels in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis

Daniel E. Furst, Jonathan Kay, Mary Chester Wasko, Edward Keystone, Arthur Kavanaugh, Atul Deodhar, Frederick T. Murphy, Jeanette H. Magnus, Elizabeth C. Hsia, Benjamin Hsu, Stephen Xu, Mahboob U. Rahman, Mittie K. Doyle

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Abstract

Objective: To evaluate the effect of golimumab on haemoglobin levels in patients with RA, PsA or AS. Methods: Secondary analysis was performed on integrated data from five randomized controlled studies: three RA, one PsA and one AS (2303 patients total). Golimumab 50 or 100 mg was injected s.c. every 4 weeks with or without MTX. Control groups received placebo injections plus MTX or background therapy. Patients with haemoglobin levels below the age- and sex-specific normal ranges were considered to have anaemia. Ferritin levels were used to distinguish anaemia of mixed aetiology (≥15 and <60 ng/ml) and anaemia of inflammation (≥60 ng/ml). Changes from baseline to weeks 14 and 24 in haemoglobin level were compared between treatment groups using an analysis of variance on the van der Waerden normal scores. Results: At baseline, 21% of RA patients, 9% of PsA patients and 15% of AS patients had anaemia. Of these, 24%, 57% and 25%, respectively, had anaemia of inflammation. The median increase from baseline to week 14 in the haemoglobin level of anaemic patients was 0.3 g/dl in the control group and 0.9 g/dl in the golimumab group (P < 0.001). Haemoglobin levels improved within the subgroups of patients with anaemia of mixed aetiology (control, 0.4 g/dl vs golimumab, 0.7 g/dl) (P = 0.305) and with anaemia of inflammation (0.2 vs 1.4 g/dl, respectively) (P < 0.001).Conclusion: Compared with the control group, patients receiving golimumab treatment had significantly improved haemoglobin levels, particularly among patients with anaemia of inflammation.

Original languageEnglish (US)
Article numberket233
Pages (from-to)1845-1855
Number of pages11
JournalRheumatology (United Kingdom)
Volume52
Issue number10
DOIs
StatePublished - Oct 2013

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Keywords

  • Anaemia
  • Ankylosing spondylitis
  • Anti-TNF-α agent
  • Golimumab
  • Psoriatic arthritis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Furst, D. E., Kay, J., Wasko, M. C., Keystone, E., Kavanaugh, A., Deodhar, A., Murphy, F. T., Magnus, J. H., Hsia, E. C., Hsu, B., Xu, S., Rahman, M. U., & Doyle, M. K. (2013). The effect of golimumab on haemoglobin levels in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis. Rheumatology (United Kingdom), 52(10), 1845-1855. [ket233]. https://doi.org/10.1093/rheumatology/ket233