Abstract
We measured hemispherical cerebral blood flow and arteriovenous differences across the cerebral cortex for glucose, oxygen, and lactate during the two primary electroencephalographic patterns (high and low voltage) in unanesthetized, near-term fetal sheep. Oxygen consumption was 127 μmol/min/100 g brain in high voltage and was 14% higher in low voltage. Glucose uptake was 19 μmol/min/100 g and was 37% higher in low voltage. Cerebral blood flow was 112 ml/min/100 g and was 29% higher in low voltage. The glucose:oxygen quotient increased from 0.91 in high voltage to 1.08 in low voltage. There was a net lactate efflux of 3.2 μmol/min/100 g during low voltage compared to a net influx of 3.3 μmol/min/100 g in high voltage. During high voltage the fetal brain uses a small amount of lactate for oxidative metabolism. During low voltage, glucose uptake exceeds the oxygen uptake needed for completely aerobic consumption, and a portion of the energy utilized by the brain is produced anaerobically.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 1989 |
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Keywords
- Brain metabolism
- Electrocortical state
- Fetal brain
- Glucose
- Lactate
- Oxygen
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep. / Chao, Conrad R.; Hohimer, Alan (Roger); Bissonnette, John M.
In: Developmental Brain Research, Vol. 49, No. 1, 01.09.1989, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep
AU - Chao, Conrad R.
AU - Hohimer, Alan (Roger)
AU - Bissonnette, John M.
PY - 1989/9/1
Y1 - 1989/9/1
N2 - We measured hemispherical cerebral blood flow and arteriovenous differences across the cerebral cortex for glucose, oxygen, and lactate during the two primary electroencephalographic patterns (high and low voltage) in unanesthetized, near-term fetal sheep. Oxygen consumption was 127 μmol/min/100 g brain in high voltage and was 14% higher in low voltage. Glucose uptake was 19 μmol/min/100 g and was 37% higher in low voltage. Cerebral blood flow was 112 ml/min/100 g and was 29% higher in low voltage. The glucose:oxygen quotient increased from 0.91 in high voltage to 1.08 in low voltage. There was a net lactate efflux of 3.2 μmol/min/100 g during low voltage compared to a net influx of 3.3 μmol/min/100 g in high voltage. During high voltage the fetal brain uses a small amount of lactate for oxidative metabolism. During low voltage, glucose uptake exceeds the oxygen uptake needed for completely aerobic consumption, and a portion of the energy utilized by the brain is produced anaerobically.
AB - We measured hemispherical cerebral blood flow and arteriovenous differences across the cerebral cortex for glucose, oxygen, and lactate during the two primary electroencephalographic patterns (high and low voltage) in unanesthetized, near-term fetal sheep. Oxygen consumption was 127 μmol/min/100 g brain in high voltage and was 14% higher in low voltage. Glucose uptake was 19 μmol/min/100 g and was 37% higher in low voltage. Cerebral blood flow was 112 ml/min/100 g and was 29% higher in low voltage. The glucose:oxygen quotient increased from 0.91 in high voltage to 1.08 in low voltage. There was a net lactate efflux of 3.2 μmol/min/100 g during low voltage compared to a net influx of 3.3 μmol/min/100 g in high voltage. During high voltage the fetal brain uses a small amount of lactate for oxidative metabolism. During low voltage, glucose uptake exceeds the oxygen uptake needed for completely aerobic consumption, and a portion of the energy utilized by the brain is produced anaerobically.
KW - Brain metabolism
KW - Electrocortical state
KW - Fetal brain
KW - Glucose
KW - Lactate
KW - Oxygen
UR - http://www.scopus.com/inward/record.url?scp=0024442205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024442205&partnerID=8YFLogxK
U2 - 10.1016/0165-3806(89)90054-0
DO - 10.1016/0165-3806(89)90054-0
M3 - Article
C2 - 2791258
AN - SCOPUS:0024442205
VL - 49
SP - 1
EP - 5
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 1
ER -