The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: A pilot study

Heather Zwickey, Julie Brush, Carolyn M. Iacullo, Erin Connelly, William L. Gregory, Amala Soumyanath, Randal Buresh

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

This phase 0, double-blind, repeated within subject, randomized pilot study examined CD25 expression on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination. CD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza. CD25 expression remains elevated with daily use of Echinacea for at least 7 days.

Original languageEnglish (US)
Pages (from-to)1109-1112
Number of pages4
JournalPhytotherapy Research
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

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Keywords

  • Adaptogens
  • Botanicals
  • CD25
  • CD4 T cells
  • Clinical trial
  • Herbs

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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