The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: A pilot study

Heather Zwickey; Julie Brush; Carolyn M. Iacullo; Erin Connelly; William L. Gregory; Amala Soumyanath; Randal Buresh

doi:10.1002/ptr.2207

The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: A pilot study

Heather Zwickey, Julie Brush, Carolyn M. Iacullo, Erin Connelly, William L. Gregory, Amala Soumyanath, Randal Buresh

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This phase 0, double-blind, repeated within subject, randomized pilot study examined CD25 expression on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination. CD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza. CD25 expression remains elevated with daily use of Echinacea for at least 7 days.

Original language	English (US)
Pages (from-to)	1109-1112
Number of pages	4
Journal	Phytotherapy Research
Volume	21
Issue number	11
DOIs	https://doi.org/10.1002/ptr.2207
State	Published - Nov 2007
Externally published	Yes

Keywords

Adaptogens
Botanicals
CD25
CD4 T cells
Clinical trial
Herbs

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1002/ptr.2207

Cite this

@article{043fd523dca14eba9bef0bf11fe1c36e,

title = "The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: A pilot study",

abstract = "This phase 0, double-blind, repeated within subject, randomized pilot study examined CD25 expression on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination. CD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza. CD25 expression remains elevated with daily use of Echinacea for at least 7 days.",

keywords = "Adaptogens, Botanicals, CD25, CD4 T cells, Clinical trial, Herbs",

author = "Heather Zwickey and Julie Brush and Iacullo, {Carolyn M.} and Erin Connelly and Gregory, {William L.} and Amala Soumyanath and Randal Buresh",

note = "Funding Information: Supported in part by grants from the KIDNEEDS foundation, the Northwest Kidney Centers Foundation, pilot project funds from the National Institutes of Health (grant U19 AI41320 and grant A144160 ), and a grant from the Else Kr{\"o}ner-Fresenius-Stiftung, Bad Homburg v. d. H{\"o}he, Germany. ",

year = "2007",

month = nov,

doi = "10.1002/ptr.2207",

language = "English (US)",

volume = "21",

pages = "1109--1112",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "11",

}

TY - JOUR

T1 - The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans

T2 - A pilot study

AU - Zwickey, Heather

AU - Brush, Julie

AU - Iacullo, Carolyn M.

AU - Connelly, Erin

AU - Gregory, William L.

AU - Soumyanath, Amala

AU - Buresh, Randal

N1 - Funding Information: Supported in part by grants from the KIDNEEDS foundation, the Northwest Kidney Centers Foundation, pilot project funds from the National Institutes of Health (grant U19 AI41320 and grant A144160 ), and a grant from the Else Kröner-Fresenius-Stiftung, Bad Homburg v. d. Höhe, Germany.

PY - 2007/11

Y1 - 2007/11

N2 - This phase 0, double-blind, repeated within subject, randomized pilot study examined CD25 expression on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination. CD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza. CD25 expression remains elevated with daily use of Echinacea for at least 7 days.

AB - This phase 0, double-blind, repeated within subject, randomized pilot study examined CD25 expression on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination. CD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza. CD25 expression remains elevated with daily use of Echinacea for at least 7 days.

KW - Adaptogens

KW - Botanicals

KW - CD25

KW - CD4 T cells

KW - Clinical trial

KW - Herbs

UR - http://www.scopus.com/inward/record.url?scp=36549003590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549003590&partnerID=8YFLogxK

U2 - 10.1002/ptr.2207

DO - 10.1002/ptr.2207

M3 - Article

C2 - 17661330

AN - SCOPUS:36549003590

SN - 0951-418X

VL - 21

SP - 1109

EP - 1112

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 11

ER -

The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this