The effect of dietary interventions to reduce blood pressure in normal humans

F. C. Luft, J. Z. Miller, R. M. Lyle, C. L. Melby, N. S. Fineberg, D. A. McCarron, M. H. Weinberger, Cynthia Morris

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Changes in electrolyte intake have been advocated to lower the prevalence of hypertension in the normal population. To elucidate the potential impact of such strategies, we conducted a comprehensive analysis of data from three interventions, namely, salt (NaCl) restriction, calcium (Ca) supplementation, and potassium (K) supplementation in normal volunteers. Eighty-two adults lowered their Na intake from 157 ± 6 S.E. to 68 ± 3 mEq/day for 12 weeks. Population mean systolic and diastolic blood pressure decreased ≤2 mm Hg. Ca supplementation, 1.5 g daily for 12 weeks in 37 men, decreased blood pressure compared to 38 men receiving placebo. Ca supplementation, 1 g daily for 8 weeks in an older group of 44 normal subjects, decreased supine diastolic and standing systolic blood pressure. K supplementation with a nonchloride salt in 64 normal adults for 4 weeks had no effect on systolic or diastolic blood pressure even though urinary excretion was increased by 20 mmol/day. The responses to all interventions were Gaussian in distribution. A potentially adverse effect on blood pressure in some normal individuals cannot be excluded on the basis of the currently available data. Although all three interventions may benefit some hypertensive and some normal individuals, the data from these relatively short-term cross-sectional studies are insufficient to warrant generalized dietary recommendations for the normal population.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalJournal of the American College of Nutrition
Volume8
Issue number6
StatePublished - 1989

Fingerprint

systolic blood pressure
blood pressure
diastolic blood pressure
Blood Pressure
calcium
salts
dietary recommendations
cross-sectional studies
sodium chloride
hypertension
electrolytes
placebos
volunteers
data analysis
excretion
Calcium
adverse effects
potassium
Salts
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Luft, F. C., Miller, J. Z., Lyle, R. M., Melby, C. L., Fineberg, N. S., McCarron, D. A., ... Morris, C. (1989). The effect of dietary interventions to reduce blood pressure in normal humans. Journal of the American College of Nutrition, 8(6), 495-503.

The effect of dietary interventions to reduce blood pressure in normal humans. / Luft, F. C.; Miller, J. Z.; Lyle, R. M.; Melby, C. L.; Fineberg, N. S.; McCarron, D. A.; Weinberger, M. H.; Morris, Cynthia.

In: Journal of the American College of Nutrition, Vol. 8, No. 6, 1989, p. 495-503.

Research output: Contribution to journalArticle

Luft, FC, Miller, JZ, Lyle, RM, Melby, CL, Fineberg, NS, McCarron, DA, Weinberger, MH & Morris, C 1989, 'The effect of dietary interventions to reduce blood pressure in normal humans', Journal of the American College of Nutrition, vol. 8, no. 6, pp. 495-503.
Luft FC, Miller JZ, Lyle RM, Melby CL, Fineberg NS, McCarron DA et al. The effect of dietary interventions to reduce blood pressure in normal humans. Journal of the American College of Nutrition. 1989;8(6):495-503.
Luft, F. C. ; Miller, J. Z. ; Lyle, R. M. ; Melby, C. L. ; Fineberg, N. S. ; McCarron, D. A. ; Weinberger, M. H. ; Morris, Cynthia. / The effect of dietary interventions to reduce blood pressure in normal humans. In: Journal of the American College of Nutrition. 1989 ; Vol. 8, No. 6. pp. 495-503.
@article{4f4b7d04eda94e41945c8813e7f1c8ac,
title = "The effect of dietary interventions to reduce blood pressure in normal humans",
abstract = "Changes in electrolyte intake have been advocated to lower the prevalence of hypertension in the normal population. To elucidate the potential impact of such strategies, we conducted a comprehensive analysis of data from three interventions, namely, salt (NaCl) restriction, calcium (Ca) supplementation, and potassium (K) supplementation in normal volunteers. Eighty-two adults lowered their Na intake from 157 ± 6 S.E. to 68 ± 3 mEq/day for 12 weeks. Population mean systolic and diastolic blood pressure decreased ≤2 mm Hg. Ca supplementation, 1.5 g daily for 12 weeks in 37 men, decreased blood pressure compared to 38 men receiving placebo. Ca supplementation, 1 g daily for 8 weeks in an older group of 44 normal subjects, decreased supine diastolic and standing systolic blood pressure. K supplementation with a nonchloride salt in 64 normal adults for 4 weeks had no effect on systolic or diastolic blood pressure even though urinary excretion was increased by 20 mmol/day. The responses to all interventions were Gaussian in distribution. A potentially adverse effect on blood pressure in some normal individuals cannot be excluded on the basis of the currently available data. Although all three interventions may benefit some hypertensive and some normal individuals, the data from these relatively short-term cross-sectional studies are insufficient to warrant generalized dietary recommendations for the normal population.",
author = "Luft, {F. C.} and Miller, {J. Z.} and Lyle, {R. M.} and Melby, {C. L.} and Fineberg, {N. S.} and McCarron, {D. A.} and Weinberger, {M. H.} and Cynthia Morris",
year = "1989",
language = "English (US)",
volume = "8",
pages = "495--503",
journal = "Journal of the American College of Nutrition",
issn = "0731-5724",
publisher = "American College Of Nutrition",
number = "6",

}

TY - JOUR

T1 - The effect of dietary interventions to reduce blood pressure in normal humans

AU - Luft, F. C.

AU - Miller, J. Z.

AU - Lyle, R. M.

AU - Melby, C. L.

AU - Fineberg, N. S.

AU - McCarron, D. A.

AU - Weinberger, M. H.

AU - Morris, Cynthia

PY - 1989

Y1 - 1989

N2 - Changes in electrolyte intake have been advocated to lower the prevalence of hypertension in the normal population. To elucidate the potential impact of such strategies, we conducted a comprehensive analysis of data from three interventions, namely, salt (NaCl) restriction, calcium (Ca) supplementation, and potassium (K) supplementation in normal volunteers. Eighty-two adults lowered their Na intake from 157 ± 6 S.E. to 68 ± 3 mEq/day for 12 weeks. Population mean systolic and diastolic blood pressure decreased ≤2 mm Hg. Ca supplementation, 1.5 g daily for 12 weeks in 37 men, decreased blood pressure compared to 38 men receiving placebo. Ca supplementation, 1 g daily for 8 weeks in an older group of 44 normal subjects, decreased supine diastolic and standing systolic blood pressure. K supplementation with a nonchloride salt in 64 normal adults for 4 weeks had no effect on systolic or diastolic blood pressure even though urinary excretion was increased by 20 mmol/day. The responses to all interventions were Gaussian in distribution. A potentially adverse effect on blood pressure in some normal individuals cannot be excluded on the basis of the currently available data. Although all three interventions may benefit some hypertensive and some normal individuals, the data from these relatively short-term cross-sectional studies are insufficient to warrant generalized dietary recommendations for the normal population.

AB - Changes in electrolyte intake have been advocated to lower the prevalence of hypertension in the normal population. To elucidate the potential impact of such strategies, we conducted a comprehensive analysis of data from three interventions, namely, salt (NaCl) restriction, calcium (Ca) supplementation, and potassium (K) supplementation in normal volunteers. Eighty-two adults lowered their Na intake from 157 ± 6 S.E. to 68 ± 3 mEq/day for 12 weeks. Population mean systolic and diastolic blood pressure decreased ≤2 mm Hg. Ca supplementation, 1.5 g daily for 12 weeks in 37 men, decreased blood pressure compared to 38 men receiving placebo. Ca supplementation, 1 g daily for 8 weeks in an older group of 44 normal subjects, decreased supine diastolic and standing systolic blood pressure. K supplementation with a nonchloride salt in 64 normal adults for 4 weeks had no effect on systolic or diastolic blood pressure even though urinary excretion was increased by 20 mmol/day. The responses to all interventions were Gaussian in distribution. A potentially adverse effect on blood pressure in some normal individuals cannot be excluded on the basis of the currently available data. Although all three interventions may benefit some hypertensive and some normal individuals, the data from these relatively short-term cross-sectional studies are insufficient to warrant generalized dietary recommendations for the normal population.

UR - http://www.scopus.com/inward/record.url?scp=0024775464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024775464&partnerID=8YFLogxK

M3 - Article

C2 - 2695549

AN - SCOPUS:0024775464

VL - 8

SP - 495

EP - 503

JO - Journal of the American College of Nutrition

JF - Journal of the American College of Nutrition

SN - 0731-5724

IS - 6

ER -