The effect of citalopram on midbrain CRF receptors 1 and 2 in a primate model of stress-induced amenorrhea

Olga Senashova, Arubala Reddy, Judy L. Cameron, Cynthia Bethea

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    We have demonstrated marked differences in the neurobiology of the serotonin system between stress-sensitive (SS) and stress-resilient (SR) cynomolgus macaques characterized in a model of stress-induced amenorrhea, also called functional hypothalamic amenorrhea (FHA). Dysfunction of the serotonin system in SS monkeys suggested that administration of a selective serotonin reuptake inhibitor (SSRI) might correct FHA. This study examines the effect of escitalopram (CIT) administration to SS and SR monkeys on corticotrophin- releasing factor (CRF) receptor 1 (CRF-R1) and CRF receptor 2 (CRF-R2) gene expression in the serotonin cell body region of the midbrain dorsal raphe. CRF-R1 was not significantly different between groups. There was a significant effect of treatment and a significant interaction between treatment and stress sensitivity on the average CRF-R2-positive pixel area (P

    Original languageEnglish (US)
    Pages (from-to)623-632
    Number of pages10
    JournalReproductive Sciences
    Volume19
    Issue number6
    DOIs
    StatePublished - Jun 2012

    Fingerprint

    Citalopram
    Amenorrhea
    Mesencephalon
    Primates
    Serotonin
    Corticotropin-Releasing Hormone
    Haplorhini
    Body Regions
    Neurobiology
    Serotonin Uptake Inhibitors
    Macaca
    Gene Expression
    CRF receptor type 2
    CRF receptor type 1

    Keywords

    • and macaques
    • corticotropin-releasing hormone receptors
    • dorsal raphe
    • selective serotonin reuptake inhibitor
    • serotonin
    • stress

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    The effect of citalopram on midbrain CRF receptors 1 and 2 in a primate model of stress-induced amenorrhea. / Senashova, Olga; Reddy, Arubala; Cameron, Judy L.; Bethea, Cynthia.

    In: Reproductive Sciences, Vol. 19, No. 6, 06.2012, p. 623-632.

    Research output: Contribution to journalArticle

    Senashova, Olga ; Reddy, Arubala ; Cameron, Judy L. ; Bethea, Cynthia. / The effect of citalopram on midbrain CRF receptors 1 and 2 in a primate model of stress-induced amenorrhea. In: Reproductive Sciences. 2012 ; Vol. 19, No. 6. pp. 623-632.
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