The effect of cimetidine and ranitidine on the duration of action of succinylcholine

Glenn Woodworth, D. H. Sears, T. M. Grove, R. H. Ruff, P. S. Kosek, R. L. Katz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A recent study suggested that cimetidine prolongs the duration of action of succinylcholine (SCh). We examined this reported interaction, and investigated whether it is the result of inhibition of plasma cholinesterase (PChE). We also studied the effect of ranitidine on the duration of action of succinylcholine. Thirty patients were randomly assigned to three groups to receive oral cimetidine 300 mg or ranitidine 150 mg or no H2-antagonist the night before surgery and again 1-2 hours prior to induction of anesthesia. Succinylcholine (1.5 mg/kg i.v.) was given to facilitate tracheal intubation after induction of anesthesia; neuromuscular function was monitored by evoked compound electromyogram. Pretreatment blood samples were analyzed for PChE activity. PChE activity and levels of appropriate H2-antagonists were measured in preinduction blood samples. No significant effect of either cimetidine or ranitidine on the duration of action of SCh or PChE activity was demonstrated. We conclude that H2-antagonists administered preoperatively do not prolong the duration of action of succinylcholine or alter PChE activity.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalAnesthesia and Analgesia
Volume68
Issue number3
StatePublished - 1989
Externally publishedYes

Fingerprint

Succinylcholine
Ranitidine
Cimetidine
Cholinesterases
Anesthesia
Electromyography
Intubation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Woodworth, G., Sears, D. H., Grove, T. M., Ruff, R. H., Kosek, P. S., & Katz, R. L. (1989). The effect of cimetidine and ranitidine on the duration of action of succinylcholine. Anesthesia and Analgesia, 68(3), 295-297.

The effect of cimetidine and ranitidine on the duration of action of succinylcholine. / Woodworth, Glenn; Sears, D. H.; Grove, T. M.; Ruff, R. H.; Kosek, P. S.; Katz, R. L.

In: Anesthesia and Analgesia, Vol. 68, No. 3, 1989, p. 295-297.

Research output: Contribution to journalArticle

Woodworth, G, Sears, DH, Grove, TM, Ruff, RH, Kosek, PS & Katz, RL 1989, 'The effect of cimetidine and ranitidine on the duration of action of succinylcholine', Anesthesia and Analgesia, vol. 68, no. 3, pp. 295-297.
Woodworth, Glenn ; Sears, D. H. ; Grove, T. M. ; Ruff, R. H. ; Kosek, P. S. ; Katz, R. L. / The effect of cimetidine and ranitidine on the duration of action of succinylcholine. In: Anesthesia and Analgesia. 1989 ; Vol. 68, No. 3. pp. 295-297.
@article{82056c6100344e1c89d4d159f1f38b2b,
title = "The effect of cimetidine and ranitidine on the duration of action of succinylcholine",
abstract = "A recent study suggested that cimetidine prolongs the duration of action of succinylcholine (SCh). We examined this reported interaction, and investigated whether it is the result of inhibition of plasma cholinesterase (PChE). We also studied the effect of ranitidine on the duration of action of succinylcholine. Thirty patients were randomly assigned to three groups to receive oral cimetidine 300 mg or ranitidine 150 mg or no H2-antagonist the night before surgery and again 1-2 hours prior to induction of anesthesia. Succinylcholine (1.5 mg/kg i.v.) was given to facilitate tracheal intubation after induction of anesthesia; neuromuscular function was monitored by evoked compound electromyogram. Pretreatment blood samples were analyzed for PChE activity. PChE activity and levels of appropriate H2-antagonists were measured in preinduction blood samples. No significant effect of either cimetidine or ranitidine on the duration of action of SCh or PChE activity was demonstrated. We conclude that H2-antagonists administered preoperatively do not prolong the duration of action of succinylcholine or alter PChE activity.",
author = "Glenn Woodworth and Sears, {D. H.} and Grove, {T. M.} and Ruff, {R. H.} and Kosek, {P. S.} and Katz, {R. L.}",
year = "1989",
language = "English (US)",
volume = "68",
pages = "295--297",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The effect of cimetidine and ranitidine on the duration of action of succinylcholine

AU - Woodworth, Glenn

AU - Sears, D. H.

AU - Grove, T. M.

AU - Ruff, R. H.

AU - Kosek, P. S.

AU - Katz, R. L.

PY - 1989

Y1 - 1989

N2 - A recent study suggested that cimetidine prolongs the duration of action of succinylcholine (SCh). We examined this reported interaction, and investigated whether it is the result of inhibition of plasma cholinesterase (PChE). We also studied the effect of ranitidine on the duration of action of succinylcholine. Thirty patients were randomly assigned to three groups to receive oral cimetidine 300 mg or ranitidine 150 mg or no H2-antagonist the night before surgery and again 1-2 hours prior to induction of anesthesia. Succinylcholine (1.5 mg/kg i.v.) was given to facilitate tracheal intubation after induction of anesthesia; neuromuscular function was monitored by evoked compound electromyogram. Pretreatment blood samples were analyzed for PChE activity. PChE activity and levels of appropriate H2-antagonists were measured in preinduction blood samples. No significant effect of either cimetidine or ranitidine on the duration of action of SCh or PChE activity was demonstrated. We conclude that H2-antagonists administered preoperatively do not prolong the duration of action of succinylcholine or alter PChE activity.

AB - A recent study suggested that cimetidine prolongs the duration of action of succinylcholine (SCh). We examined this reported interaction, and investigated whether it is the result of inhibition of plasma cholinesterase (PChE). We also studied the effect of ranitidine on the duration of action of succinylcholine. Thirty patients were randomly assigned to three groups to receive oral cimetidine 300 mg or ranitidine 150 mg or no H2-antagonist the night before surgery and again 1-2 hours prior to induction of anesthesia. Succinylcholine (1.5 mg/kg i.v.) was given to facilitate tracheal intubation after induction of anesthesia; neuromuscular function was monitored by evoked compound electromyogram. Pretreatment blood samples were analyzed for PChE activity. PChE activity and levels of appropriate H2-antagonists were measured in preinduction blood samples. No significant effect of either cimetidine or ranitidine on the duration of action of SCh or PChE activity was demonstrated. We conclude that H2-antagonists administered preoperatively do not prolong the duration of action of succinylcholine or alter PChE activity.

UR - http://www.scopus.com/inward/record.url?scp=0024523220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024523220&partnerID=8YFLogxK

M3 - Article

C2 - 2919769

AN - SCOPUS:0024523220

VL - 68

SP - 295

EP - 297

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 3

ER -