The effect of cervical sympathectomy on cochlear electrophysiology

Elisabeth Hultcrantz, Alfred Nuttall, M. Christian Brown, Merle Lawrence

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The purpose of this study was to examine the electrophysiologic responens to sound from guinea pig cochleas, 3-6 days after a unilateral cervical sympathec-tomy. After recovery from surgery the guinea pigs developed a Horner's syndrome on the sympathectomized side. Some days later their bullas were opened and electrodes were placed bilaterally on the round windows. Most of the sympathectomized cochleas showed signs of decreased sensitivity to sound. They had a smaller dynamic range for the click- and tone-burst evoked compound action potential (CAP) compared with the non-sympathectomized cochleas. The threshold sound levels for the CAPs and the sound levels to produce 1 μV of cochlear microphonic potentials were unaffected. In other animals with chronic implanted electrodes, the same electrical responses were measured with only light sedation before and after sympa-thectomy and showed the same results. In additional animals the crossed olivocochlear bundle (COCB) was electrically stimulated and a similar inhibition of the CAP was registered on both the intact and the sympathectomized side.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalActa Oto-Laryngologica
Volume94
Issue number1-6
DOIs
StatePublished - 1982
Externally publishedYes

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Sympathectomy
Electrophysiology
Cochlea
Action Potentials
Guinea Pigs
Cochlear Microphonic Potentials
Horner Syndrome
Implanted Electrodes
Electrodes
Light

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

The effect of cervical sympathectomy on cochlear electrophysiology. / Hultcrantz, Elisabeth; Nuttall, Alfred; Brown, M. Christian; Lawrence, Merle.

In: Acta Oto-Laryngologica, Vol. 94, No. 1-6, 1982, p. 439-444.

Research output: Contribution to journalArticle

Hultcrantz, Elisabeth ; Nuttall, Alfred ; Brown, M. Christian ; Lawrence, Merle. / The effect of cervical sympathectomy on cochlear electrophysiology. In: Acta Oto-Laryngologica. 1982 ; Vol. 94, No. 1-6. pp. 439-444.
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