The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis

Debra L. Breneman, Jon M. Hanifin, Cynthia A. Berge, Bruce H. Keswick, Paula B. Neumann

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

This double-blind study determined whether daily bathing with an antibacterial soap would reduce the number of Staphylococcus aureus on the skin and result in clinical improvement of atopic dermatitis. For 9 weeks, 50 patients with moderately severe atopic dermatitis bathed daily with either an antimicrobial soap containing 1.5% triclocarban or the placebo soap. They also used a nonmedicated moisturizer and 0.025% triamcinolone acetonide cream as needed, but the availability of the corticosteroid cream was discontinued after 6 weeks. The antimicrobial soap regimen caused significantly greater improvement in the severity and extent of skin lesions than the placebo soap regimen, which correlated with reductions both in S aureus in patients with positive cultures at baseline and in total aerobic organisms. Outcome measures included reductions in S aureus, total aerobic organisms, and dermatologic assessments. Overall, daily bathing with an antibacterial soap was well tolerated, provided clinical improvement, and reduced levels of skin microorganisms.

Original languageEnglish (US)
Pages (from-to)296-300
Number of pages5
JournalCutis
Volume66
Issue number4
StatePublished - Oct 1 2000

ASJC Scopus subject areas

  • Dermatology

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    Breneman, D. L., Hanifin, J. M., Berge, C. A., Keswick, B. H., & Neumann, P. B. (2000). The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. Cutis, 66(4), 296-300.