The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis

Debra L. Breneman, Jon Hanifin, Cynthia A. Berge, Bruce H. Keswick, Paula B. Neumann

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This double-blind study determined whether daily bathing with an antibacterial soap would reduce the number of Staphylococcus aureus on the skin and result in clinical improvement of atopic dermatitis. For 9 weeks, 50 patients with moderately severe atopic dermatitis bathed daily with either an antimicrobial soap containing 1.5% triclocarban or the placebo soap. They also used a nonmedicated moisturizer and 0.025% triamcinolone acetonide cream as needed, but the availability of the corticosteroid cream was discontinued after 6 weeks. The antimicrobial soap regimen caused significantly greater improvement in the severity and extent of skin lesions than the placebo soap regimen, which correlated with reductions both in S aureus in patients with positive cultures at baseline and in total aerobic organisms. Outcome measures included reductions in S aureus, total aerobic organisms, and dermatologic assessments. Overall, daily bathing with an antibacterial soap was well tolerated, provided clinical improvement, and reduced levels of skin microorganisms.

Original languageEnglish (US)
Pages (from-to)296-300
Number of pages5
JournalCutis
Volume66
Issue number4
StatePublished - Oct 2000

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Soaps
Atopic Dermatitis
Staphylococcus aureus
Skin
Placebos
Triamcinolone Acetonide
Double-Blind Method
triclocarban
Adrenal Cortex Hormones
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Breneman, D. L., Hanifin, J., Berge, C. A., Keswick, B. H., & Neumann, P. B. (2000). The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. Cutis, 66(4), 296-300.

The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. / Breneman, Debra L.; Hanifin, Jon; Berge, Cynthia A.; Keswick, Bruce H.; Neumann, Paula B.

In: Cutis, Vol. 66, No. 4, 10.2000, p. 296-300.

Research output: Contribution to journalArticle

Breneman, DL, Hanifin, J, Berge, CA, Keswick, BH & Neumann, PB 2000, 'The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis', Cutis, vol. 66, no. 4, pp. 296-300.
Breneman, Debra L. ; Hanifin, Jon ; Berge, Cynthia A. ; Keswick, Bruce H. ; Neumann, Paula B. / The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. In: Cutis. 2000 ; Vol. 66, No. 4. pp. 296-300.
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