The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures

Robert M. Levy, Howard L. Fields, Michael P. Stryker, Mary M. Heinricher

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The effect of morphine on regional cerebral glucose metabolism was measured in rats using high resolution [14C]2-deoxyglucose autoradiography with concurrent confirmation of morphine-induced analgesia measured by tail-flick latency to noxious heat. Within the limits of resolution of this technique, doses of morphine sufficient to inhibit the tail-flick reflex had no significant effect on glucose metabolism in structures implicated in the modulation of pain.

Original languageEnglish (US)
Pages (from-to)170-173
Number of pages4
JournalBrain research
Volume368
Issue number1
DOIs
StatePublished - Mar 12 1986

Keywords

  • [C]2-deoxyglucose autoradiography
  • analgesia
  • morphine
  • pain
  • regional cerebral metabolism

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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