The effect of anaesthetic agents on the cerebrospinal fluid clearance of 35S-sulphate and 125I-iodide

A. V. Lorenzo, John Hammerstad, R. W P Cutler

Research output: Contribution to journalArticle

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Abstract

In recent years, use of the ventriculocisternal perfusion technique for the study of cerebrospinal fluid transport of substances has become prevalent. This report compares the effect of three anesthetic agents, commonly used in the laboratory, on the clearance of 35S-sulfate and 125I-iodide out of the CSF. When compared with chloralose, pentobarbital and (to a lesser extent) urethane inhibit the CSF clearance of these anions. In studies with isolated choroid plexus incubated in vitro, the accumulation of 125I-iodide was found to be significantly less in the choroid plexus obtained from the anesthetized than from the unanesthetized animal. These results suggest that the reduced CSF clearance observed in vivo was a result, at least in part, of inhibition of choroid plexus transport.

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalBiochemical Pharmacology
Volume17
Issue number7
StatePublished - Jul 1968
Externally publishedYes

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Cerebrospinal fluid
Choroid Plexus
Iodides
Sulfates
Cerebrospinal Fluid
Anesthetics
Chloralose
Urethane
Pentobarbital
Anions
Animals
Perfusion

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of anaesthetic agents on the cerebrospinal fluid clearance of 35S-sulphate and 125I-iodide. / Lorenzo, A. V.; Hammerstad, John; Cutler, R. W P.

In: Biochemical Pharmacology, Vol. 17, No. 7, 07.1968, p. 1279-1283.

Research output: Contribution to journalArticle

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