The effect of an intraduodenal elemental diet on pancreatic secretion

B. M. Wolfe, R. M. Keltner, D. L. Kaminski

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The effect of an elemental diet on canine exocrine pancreatic secretion was evaluated by infusing an elemental diet into the duodenum of dogs and monitoring the output of the pancreas. The stimulatory properties of the elemental diet were compared with a nearly equimolar dose of an L form neutral amino acid, 0.16 normal hydrochloric acid, and 2 units/kg per hr of exogenous cholecystokinin. Intraduodenal infusion of elemental diet produced significant increases in pancreatic volume and protein output. These changes were similar to those produced by the amino acid solution, and suggest that the stimulatory properties of the elemental diet are primarily due to the amino acid content. The results of this study suggest that elemental diets stimulate the duodenal mucosa to secrete cholecystokinin which stimulates the exocrine pancreas. Elemental diets administered in such a manner that the substance passes through the duodenum would not theoretically be a satisfactory method of providing calories to patients with acute pancreatitis.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalSurgery Gynecology and Obstetrics
Volume140
Issue number2
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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